Aminodipeptidase inhibitor-induced cell death in quiescent lymphocytes: a review.
Aminodipeptidase inhibitor-induced cell death in quiescent lymphocytes: a review.
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氨基二肽酶抑制剂诱导的静止淋巴细胞细胞死亡：综述。
DOI：
10.1023/a:1009675223443
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Huber,BT
中科院分区：
文献类型：
--
作者：
Chiravuri,M;Huber,BT
我们最近分离并克隆了一种细胞内脯氨酸裂解后氨基二肽酶，静止细胞脯氨酸二肽酶（QPP），它具有与二肽基肽酶IV（CD 26/DPPIV）非常相似的底物特异性。脯氨酸氨基二肽酶的高度特异性抑制剂激活静止淋巴细胞中的新凋亡途径。这些抑制剂的靶点不是CD 26/DPPIV，而是QPP。由氨基二肽酶抑制剂诱导的凋亡途径是不寻常的，因为它仅限于静止的淋巴细胞，而不是活化或转化的淋巴细胞。在这种凋亡途径中激活的半胱天冬酶不同于Fas或γ-辐射介导的细胞死亡途径中激活的半胱天冬酶，此外，蛋白酶体似乎在这种死亡途径中发挥作用。包括趋化因子和细胞因子在内的大量信号分子在N-末端具有高度保守的X-Pro基序，使它们成为QPP的潜在底物和静息淋巴细胞存活的参与者。
We recently isolated and cloned an intracellular post-proline cleaving aminodipeptidase, quiescent cell proline dipeptidase (QPP), which has a substrate specificity very similar to that of dipeptidyl peptidase IV (CD26/DPPIV). Highly specific inhibitors of proline aminodipeptidases activate a novel apoptotic pathway in quiescent lymphocytes. The target of these inhibitors is not CD26/DPPIV, but appears to be QPP. The apoptosis pathway induced by the aminodipeptidase inhibitors is unusual in that it is restricted to quiescent lymphocytes, but not activated or transformed lymphocytes. The caspases activated in this apoptotic pathway are different from those activated in Fas or gamma-irradiation mediated cell death pathways, and furthermore, the proteasome appears to play a role in this death pathway. A large number of signal molecules including chemokines and cytokines have a highly conserved X-Pro motif on the N-terminus, rendering them potential substrates of QPP and players in the survival of resting lymphocytes.