Molecular genetics of AMD and current animal models
Molecular genetics of AMD and current animal models
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DOI：
10.1007/s10456-007-9064-2
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发表时间：
2007-01-01
期刊：
影响因子：
9.8
通讯作者：
Malek, Goldis
中科院分区：
文献类型：
--
作者：
Edwards, Albert O.;Malek, Goldis
在过去的几年中，对年龄相关性黄斑变性（AMD）的流行病学、遗传学和病理生理学的系统调查为老年人视力丧失的主要原因提供了重要的新见解。这些研究提供了一种观点，即AMD是一种复杂的性状，受到公认的遗传和环境风险的影响，导致炎症沉积在外视网膜。这种黄斑病变通过多种机制和并发症导致视觉功能障碍，可以在人类和动物模型中观察到。在这篇综述中，将总结与人类AMD相关的风险以及用于研究AMD及其并发症的动物模型。没有努力进行AMD遗传学和动物模型的所有领域的全面引用，而是选择观察和支持参考资料说明了该领域的现状。
During the past few years systematic investigation into the epidemiology, genetics, and pathophysiology of age-related macular degeneration (AMD) has provided important new insight into this leading cause of vision loss in older persons. These studies provide a view of AMD as a complex trait influenced by well-established genetic and environmental risks that leads to the deposition of inflammatory deposits in the outer retina. This maculopathy leads to visual dysfunction through a variety of mechanisms and complications that can be observed in both humans and animal models. In this review, the risks associated with AMD in humans and the animal models used to study AMD and its complications will be summarized. No effort has been made to perform a comprehensive citation of all areas of AMD genetics and animal models, but rather a selection of observations and supporting references illustrative of the current state of the field is presented.