ADRENERGIC EXCITATION OF CUTANEOUS PAIN RECEPTORS INDUCED BY PERIPHERAL-NERVE INJURY
ADRENERGIC EXCITATION OF CUTANEOUS PAIN RECEPTORS INDUCED BY PERIPHERAL-NERVE INJURY
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DOI：
10.1126/science.2011742
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发表时间：
1991-03-29
期刊：
影响因子：
56.9
通讯作者：
PERL, ER
中科院分区：
文献类型：
--
作者：
SATO, J;PERL, ER
周围神经损伤有时会导致灼痛，即周围至神经损伤部位的异常灼痛，其机制尚不确定，尽管已知涉及交感神经系统。这些症状是否可能是某些皮肤痛觉感受器(C纤维伤害性感受器)对交感传出活动的反应性发展的结果，作为神经损伤的结果在动物模型中进行了测试。在神经损伤后，交感神经刺激和去甲肾上腺素对皮肤C纤维伤害性感受器的一个子集是兴奋的，并增强了这些伤害性感受器对组织损伤刺激的反应性。这些效应在神经损伤后几天内表现出来，发生在皮肤感受性终末区域，在损伤后未退化的感觉纤维中表现明显，并由α-2-肾上腺素能样受体介导。
The mechanisms by which peripheral nerve injuries sometimes lead to causalgia, aberrant burning pain peripheral to the site of nerve damage, are uncertain, although the sympathetic nervous system is known to be involved. Whether such syndromes could be the result of the development of responsiveness by some cutaneous pain receptors (C-fiber nociceptors) to sympathetic efferent activity as a consequence of the nerve injury was tested in an animal model. After nerve damage but not in its absence, sympathetic stimulation and norepinephrine were excitatory for a subset of skin C-fiber nociceptors and enhanced the responsiveness of these nociceptors to tissue-damaging stimulation. These effects were demonstrable within days after nerve lesions, occurred at the cutaneous receptive terminal region, were manifest in sensory fibers that had not degenerated after the injury, and were mediated by alpha-2-adrenergic-like receptors.