Cardiovascular Effects of Particulate Air Pollution.

Cardiovascular Effects of Particulate Air Pollution.
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DOI:
10.1146/annurev-med-042220-011549
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发表时间:
2022-01-27
影响因子:
10.5
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
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吸入化石燃料燃烧产生的细颗粒物(PM2.5)是心血管疾病的重要风险因素。暴露在PM2.5中与血压、血栓形成和胰岛素抵抗的增加有关。它还会导致血管损伤,加速动脉粥样硬化的形成。动物模型的结果证实了流行病学证据,并表明PM2.5对心血管的影响可能部分归因于氧化应激、炎症和自主神经系统的激活。尽管潜在的机制尚不清楚,但有强有力的证据表明,长期暴露在PM2.5中与心力衰竭、中风和缺血性心脏病导致的过早死亡有关。
Inhalation of fine particulate matter (PM2.5), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM2.5 has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM2.5 may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM2.5 is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.
DOI: 10.1016/j.envres.2019.108541
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