Different EEG topographic effects of painful and non-painful intramuscular stimulation in man
Different EEG topographic effects of painful and non-painful intramuscular stimulation in man
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DOI：
10.1007/s002210100864
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发表时间：
2001-11-01
影响因子：
2
通讯作者：
Chen, ACN
中科院分区：
文献类型：
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作者：
Chang, PF;Arendt-Nielsen, L;Chen, ACN
为了阐明肌肉疼痛对人类脑电图（EEG）激活的具体影响，在15名男性志愿者中，通过在左肱桡肌中肌肉注射辣椒素和溶剂溶液产生疼痛和非疼痛感觉。对两次注射前、中、后采集的31导脑电数据进行了地形图和功率谱分析比较。虽然疼痛和非疼痛的肌肉刺激诱发相似的EEG地形图模式，统计数据表明，不同的EEG激活的头部不同地区的疼痛和非疼痛的刺激诱导相比，基线。非痛性刺激引起中央和后顶叶θ和α 1（8- 10.5Hz）活动的减少，而痛性刺激引起后脑α 1和α 2（11- 13.5Hz）活动的减少。α-2活性在明显疼痛减少后疼痛减弱期间增强。比较基线、非疼痛和疼痛刺激以及疼痛减弱之间的EEG变化，我们发现，在肌肉疼痛期间，β-2活性的增加在头部的广泛区域上是显著的，而在明显疼痛明显减少后，在疼痛减弱期间，头部后部的α-2活性显著增加。这些结果可能暗示疼痛和非疼痛肌肉刺激在人脑不同的神经网络中引起不同的EEG激活，并且来自肌肉的伤害性输入的强度可能编码了各种地形EEG变化。
To clarify the specific effects of muscle pain on electroencephalogram (EEG) activation in man, painful and non-painful sensations were produced by intramuscular injections of capsaicin and vehicle solution in the left brachioradialis muscle, with identical procedures in 15 male volunteers. Thirty-one channel EEG data acquired before, during and after the two injections were analysed and compared in respect of topography and power spectrum. Although the painful and non-painful muscular stimulations evoked similar EEG topographic patterns, statistics demonstrated that distinct EEG activation over different areas of the head were induced by the painful and non-painful stimulation compared with the baselines. The decreases in theta and alpha-1 (8-10.5 Hz) activity in central and posterior parietal parts were evoked by nonpainful stimulation, but the decreases in alpha-l and alpha-2 (11-13.5 Hz) activities in the posterior part of the head were induced by painful stimulation. The alpha-2 activity augmented during the waning pain following a decrease in the overt pain. Comparing the EEG changes between baseline, non-painful and painful stimulations as well as waning pain, we found that the increase in beta-2 activity during muscle pain was significant over the extensive areas of the head, whereas a significant increase in alpha-2 activity took place at the posterior part of the head during waning pain following a marked decrease in overt pain. These results may imply that the painful and non-painful muscular stimulations evoke distinct EEG activation in different neural networks of the human brain and the intensity of nociceptive input from muscle may encode the variety of topographic EEG changes.