Foetal and neonatal outcomes in first-trimester pregnant women exposed to abdominal or lumbar radiodiagnostic procedures without administration of radionucleotides
Foetal and neonatal outcomes in first-trimester pregnant women exposed to abdominal or lumbar radiodiagnostic procedures without administration of radionucleotides
复制标题
DOI：
10.1111/imj.12043
复制
发表时间：
2013-05-01
影响因子：
2.1
通讯作者：
Nava-Ocampo, A. A.
中科院分区：
文献类型：
--
作者：
Choi, J. S.;Han, J. Y.;Nava-Ocampo, A. A.
背景/目的对妊娠早期低剂量辐射暴露和子代的确定性不良影响知之甚少，风险是从灾难性事件或放射治疗的暴露中推断出来的。这项研究旨在评估接受腹部或腰部照射的放射诊断程序的孕妇的胎儿和新生儿结局。方法在前瞻性队列设计中，我们研究了115名需要接受腹部或腰椎放射诊断程序但不使用放射性核苷酸的单身孕妇和527名年龄匹配(+/-2岁)的对照孕妇的胎儿和新生儿结局。结果在暴露组中，腰椎摄影(33.9%)、腹部平片(16.5%)和上消化道摄影合并腹部照射(15.7%)是最常见的放射诊断方法。暴露组和对照组分别有2例(1.9%)和2例(0.4%)检出严重先天畸形(优势比=4.7，95%可信区间0.733.6，P=0.15)。两组的其余胎儿和新生儿结局相似，只是暴露妇女所生婴儿的新生儿重症监护病房入院率略高(优势比=2.9；95%可信区间1.09.4；P=0.06)。结论我们的结果表明，腹部放射而不使用放射性核苷酸的X射线和CT扫描暴露与胎儿和新生儿的不良结局无关。需要努力减少对育龄妇女进行一般检查时使用放射诊断程序。
Background/Aim Little is known about exposures to low radiation doses in the first trimester of pregnancy and deterministic adverse effects in the offspring, and risks are extrapolated from catastrophic events or from exposures to radiotherapy. The study aimed to assess the foetal and neonatal outcomes of pregnant women exposed to radiodiagnostic procedures with abdominal or lumbar irradiation. Methods In a prospective cohort design, we studied the foetal and neonatal outcomes in 115 singleton pregnant women who required abdominal or lumbar radiodiagnostic procedures without the administration of radionucleotides, and in 527 age-matched (+/- 2 years) control pregnant women. Results In the exposed group, lumbar spine radiography (33.9%), plain abdominal radiography (16.5%) and upper gastrointestinal tract radiography with abdominal irradiation (15.7%) were the most common radiodiagnostic procedures. Major congenital malformations were identified in two (1.9%) babies born in the exposed group and in two (0.4%) babies born in the control group (odds ratio = 4.7; 95% confidence interval 0.733.6; P = 0.15). The rest of the foetal and neonatal outcomes was similar in the two groups except by a marginally higher rate of admissions to the neonatal intensive care unit among babies born to exposed women (odds ratio = 2.9; 95% confidence interval 1.09.4; P = 0.06). Conclusion Our results indicate that X-ray and computed tomography scan exposure involving abdominal irradiation without the administration of radionucleotides is not associated with adverse foetal and neonatal deterministic outcomes. Efforts are required to reduce the use of radiodiagnostic procedures for general check-ups in childbearing age women.