Sphingosine 1-phosphate: Lipid signaling in pathology and therapy.
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy.
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DOI：
10.1126/science.aar5551
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发表时间：
2019-10-18
期刊：
影响因子：
--
通讯作者：
Hla T
中科院分区：
文献类型：
--
作者：
Cartier A;Hla T
1-磷酸鞘氨醇（S1 P）是细胞膜鞘脂的代谢产物，与细胞外伴侣结合，在循环液中富集，并与G蛋白偶联的S1 P受体（S1 PRs）结合，以调节胚胎发育，出生后器官功能和疾病。事实上，S1 PRs调节重要的过程，如适应性免疫细胞运输，血管发育和稳态。此外，S1 PR信号是多种疾病的驱动因素。在过去的十年中，这一领域出现了指数增长，部分原因是多学科研究集中在这种脂质介质和S1 PR靶向药物在临床医学中的应用。这揭示了溶血磷脂介质信号传导的基本原理，不仅阐明了S1 P的复杂和广泛的作用，而且还指导了免疫学、心血管、神经学、炎症和纤维化疾病的治疗和转化方向的发展。
Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, enriched in circulatory fluids and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function and disease. Indeed, S1PRs regulate essential processes such as adaptive immune cell trafficking, vascular development and homeostasis. Moreover, S1PR signaling is a driver of multiples diseases. The past decade has witnessed an exponential growth in this field, in part due to multidisciplinary research focused on this lipid mediator and the application of S1PR-targeted drugs in clinical medicine. This has revealed fundamental principles of lysophospholipid mediator signaling that not only clarify the complex and wide ranging actions of S1P but also guide the development of therapeutics and translational directions in immunological, cardiovascular, neurological, inflammatory and fibrotic diseases.
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