NEUROPATHOLOGIC FINDINGS IN SHORT-TERM SURVIVORS OF INTRAVENTRICULAR HEMORRHAGE
NEUROPATHOLOGIC FINDINGS IN SHORT-TERM SURVIVORS OF INTRAVENTRICULAR HEMORRHAGE
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DOI：
10.1001/archpedi.1987.04460060035027
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发表时间：
1987-06-01
影响因子：
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通讯作者：
GODDARDFINEGOLD, J
中科院分区：
文献类型：
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作者：
ARMSTRONG, DL;SAULS, CD;GODDARDFINEGOLD, J
脑室内出血（IVH）发生在31%至43%的婴儿体重小于1500克。脑室内出血在尸检中很少是孤立的病变。为了记录相关的大脑异常，对24例诊断为IVH且存活至少一周的婴儿的大脑进行了检查。在20名婴儿中证实了诊断。两名婴儿的脉络丛出血和脑钙化被误诊为IVH，另外两名婴儿的IVH在尸检时不明显。 11名婴儿（46%）有脉络丛出血。22名婴儿（92%）有其他脑异常：脑室周围白质软化、脑干坏死、脑积水或小脑坏死。这项研究表明，IVH很少是一个孤立的异常早产儿大脑。在预防或治疗IVH时应考虑相关的脑病变，在对幸存者进行临床评估时应怀疑其存在。
Intraventriclar hemorrhage (IVH) occurs in 31% to 43% of infants weighing less than 1500 g. Intraventricular hemorrhage is rarely an isolated lesion at autopsy. To document associated cerebral abnormality, 24 brains of infants with a diagnosis of IVH and who survived for at least one week were examined. The diagnosis was verified in 20 infants. Choroid plexus hemorrhage and brain calcification had been misdiagnosed as IVH in two infants and in two other infants, IVH was not evident at autopsy. Eleven infants (46%) had choroid plexus hemorrhage. Twenty-two infants (92%) had additional cerebral abnormalities: periventricular leukomalacia, brainstem necrosis, hydrocephalus, or cerebellar necrosis. This study demonstrates that IVH is rarely an isolated abnormality in the preterm infant brain. The associated brain lesions should be considered in attempts to prevent or treat IVH and their presence should be suspected during clinical assessment of survivors.