Molecular evolutionary evidence that H19 mRNA is functional
Molecular evolutionary evidence that H19 mRNA is functional
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DOI：
10.1016/s0168-9525(99)01696-0
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发表时间：
1999-04-01
影响因子：
11.4
通讯作者：
Smith, NGC
中科院分区：
文献类型：
--
作者：
Hurst, LD;Smith, NGC
基因的外显子部分被分割成100 bp长的非重叠窗口（编号为1到22）。内含子被完整地分析并按顺序编号。我们使用ClustalW15对大鼠（X59864）和小鼠（AF049091）报道的H19的内含子和外显子序列进行比对。Y轴是使用Tamura9216作为多次命中调整方法的替换率(K)。请注意，所有内含子的取代率都高于其侧面外显子。
The exonic parts of the gene are split into non-overlapping windows 100 bp long (numbered 1 to 22). The introns are analysed whole and numbered in order. We used ClustalW15 to align the intronic and exonic sequences of H19 reported for rat (X59864) and mice (AF049091). The Y axis is the rate of substitution (K) using Tamura9216 as the method of adjusting for multiple hits. Note that all introns have higher substitution rates than their flanking exons.