Environmental Regulation of Skin Pigmentation and Hair Regeneration.
Environmental Regulation of Skin Pigmentation and Hair Regeneration.
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DOI：
10.1089/scd.2022.29011.wwu
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发表时间：
2022-03
影响因子：
4
通讯作者：
Wang Wu;Jing Yang;Hongjun Tao;Mingxing Lei
中科院分区：
文献类型：
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作者：
Wang Wu;Jing Yang;Hongjun Tao;Mingxing Lei
皮肤具有重要的附属物和不同的细胞类型，在保护、体温调节、机械感觉、立毛和社会交流中发挥重要作用。毛囊是一种微小的皮肤附属物，具有复杂的结构，在哺乳动物中具有多种功能。毛囊进化出干细胞，这些干细胞周期性地再生以产生毛发并适应快速变化的环境。黑素细胞干细胞（melanocytestemcells，McSCs）与毛囊干细胞（hairfollicstemcells，HFSCs）共享相同的突起生态位，与HFSCs同步进行周期性激活，使毛发着色，从而保护皮肤免受紫外线辐射。HFSC或MCSC的疾病导致皮肤病，如脱发、白发、白癜风，甚至黑色素瘤，损害健康感并对受影响的个体造成心理社会困扰。这些干细胞的激活或静止不仅受卵泡内内在因素的调节，而且在很大程度上受到外部环境因素的影响，包括邻近细胞，系统因素和外部环境。虽然已经取得了很大的进展，阐明HFSC或MCSC的内在调节，了解这些干细胞的环境调节可以提供新的见解，为治疗脱发和皮肤色素相关疾病的新的治疗策略的发展。
Skin bears essential appendages and diverse cell types that function importantly in protection, thermoregulation, mechanosensation, piloerection, and social communication. The hair follicle is a tiny skin appendage with intricate structure and has versatile functions in mammals. Hair follicles evolve stem cells that regenerate cyclically to produce hairs and to accommodate the rapidly changing environment. Sharing the same bulge niche with hair follicle stem cells (HFSCs), melanocyte stem cells (McSCs) undergo cyclic activation in synchrony with HFSCs, to pigment the hairs, which can protect the skin from ultraviolet radiation. Disorders of HFSCs or McSCs result in skin diseases such as hair loss, canities, vitiligo, and even melanoma, compromising senses of well-being and posing psychosocial distress to the affected individuals. The activation or quiescence of these stem cells is not only regulated by intrinsic factors within the follicle, but is also largely influenced by the extrinsic environmental factors, including the neighboring cells, systemic factors, and the external environment. Although great progress has been made to elucidate the intrinsic regulation of HFSCs or McSCs, understanding the environmental modulation of these stem cells can provide novel insight for the development of new therapeutic strategies for treating alopecia and skin pigmentation-related disorders.