SARS-CoV-2 variants and vaccination.
SARS-CoV-2 variants and vaccination.
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DOI：
10.15212/zoonoses-2022-0001
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Shi, Pei-Yong
中科院分区：
文献类型：
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作者：
Liu, Yang;Liu, Jianying;Shi, Pei-Yong
自2019年底出现以来，严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）已造成全球破坏。在过去两年中，该病毒在人类宿主中不断进化，导致病毒传播、疾病严重程度和逃避免疫的变异出现。尽管针对2019冠状病毒病（COVID-19）的疫苗以前所未有的速度开发，但变体不断对已批准疫苗的有效性构成威胁。在这篇简短的文章中，我们回顾了关键的变异，并讨论了它们在病毒复制、传播和免疫逃避中的意义。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global destruction since its emergence in late 2019. Over the past two years, the virus has continuously evolved in human host, leading to emergence of variants with changed viral transmission, disease severity, and evasion of immunity. Although vaccines have been developed for the coronavirus disease 2019 (COVID-19) at an unprecedently pace, the variants have constantly posed threats to the effectiveness of the approved vaccines. In this short communication, we review the key variants and discuss their implications in viral replication, transmission, and immune evasion.