Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules.
Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules.
复制标题
纳米材料作为激光解吸/电离飞行时间质谱的辅助基质用于小分子分析
DOI：
10.3390/nano7040087
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发表时间：
2017-04-21
期刊：
影响因子：
--
通讯作者：
Cai Z
中科院分区：
文献类型：
--
作者：
Lu M;Yang X;Yang Y;Qin P;Wu X;Cai Z
基质辅助激光解吸/电离（MALDI）是一种软电离技术，与飞行时间质谱（TOF MS）联用，已成为分析多肽、蛋白质、核酸和聚合物等大分子的重要手段。然而，由于低质量区常规基体的干扰，MALDI技术在小分子（<700 Da）分析中的应用成为一个巨大的挑战。为了克服这个缺点，在过去的十年中，更多的注意力已经支付到探索无干扰的方法。利用纳米材料作为激光解吸/电离（LDI）基体的技术，又称纳米材料辅助激光解吸/电离技术纳米材料辅助激光解吸附技术（nanomerial-assisted LDI）在飞行时间质谱（TOF MS）分析低分子量化合物中的应用已引起广泛关注。金属基和金属有机框架作为辅助基质，用于小生物分子、环境污染物和其他低分子量化合物的分析。
Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.