The effect of acute angiotensin II blockade on renal function in rats with reduced renal mass.
The effect of acute angiotensin II blockade on renal function in rats with reduced renal mass.
复制标题
急性血管紧张素 II 阻断对肾质量减少大鼠肾功能的影响。
DOI：
10.1038/ki.1994.357
复制
发表时间：
1994
影响因子：
19.6
通讯作者：
Meyer,TW
中科院分区：
文献类型：
--
作者：
Baboolal,K;Meyer,TW
急性血管紧张素II阻断对肾质量减轻大鼠肾功能的影响。采用微穿刺法观察急性阻断Ang II对肾单位数目减少大鼠肾功能的影响。血管紧张素II受体阻滞剂氯沙坦的剂量为10毫克静脉注射。在五分之五的肾脏消融术后，间隔两次。在消融后8周，Ang II受体阻滞剂增加钠排泄[UNAV，Ang IIX 2.2±0.4µEq/min；时间控制(TC)1.0±0.3µg/min；P<；0.05]，但不降低平均动脉压(AP，Ang IIX 142±6 mm Hg；TC 151±6 mm Hg)、肾小球跨毛细血管压(ΔP，Ang II X 50±1 mm Hg；TC 50±1 mm Hg)或尿白蛋白排泄(UAlbV：Ang II X 149±18；TC 168±20µg/min)。同样，在消融后两周，Ang II受体阻滞剂增加了UNaV(Ang IIX2.8±0.4；TC 0.5±0.2；P<；0.05)，而不降低AP(Ang IIX132±6 mm Hg；TC 140±7 mm Hg)、ΔP(Ang IIX 50±3 mm Hg；TC 48±2 mm Hg)或UAlb(Ang IIX 32±3；TC 36±10)。这些发现表明，在残留肾脏内，血管紧张素II促进钠滞留，但对肾小球压力或通透性选择性没有明显可逆影响。
The effect of acute angiotensin II blockade on renal function in rats with reduced renal mass. The effect of acute Ang II blockade on renal function in rats with reduced nephron number was assessed in micropuncture studies. The Ang II receptor blocker, losartan, was administered at a dose of 10 mg i.v. at two intervals following five-sixths renal ablation. At eight weeks following ablation, Ang II blockade (Ang IIX) increased sodium excretion [UNaV, Ang IIX 2.2 ± 0.4 µEq/min; time control (TC) 1.0 ± 0.3 µEg/min; P < 0.05] but did not reduce mean arterial pressure (AP, Ang IIX 142 ± 6 mm Hg; TC 151 ± 6 mm Hg), glomerular transcapillary pressure (ΔP, Ang IIX 50 ± 1 mm Hg; TC 50 ± 1 mm Hg), or urine albumin excretion (UAlbV: Ang IIX 149 ± 18 µg/min; TC 168 ± 20 µg/min). Similarly, at two weeks following ablation, Ang II blockade increased UNaV (Ang IIX 2.8 ± 0.4 µEq/min; TC 0.5 ± 0.2 µEq/min; P < 0.05) without reducing AP (Ang IIX 132 ± 6 mm Hg; TC 140 ± 7 mm Hg), ΔP (Ang IIX 50 ± 3 mm Hg; TC 48 ± 2 mm Hg), or UAlb(Ang IIX 32 ± 3 µg/min; TC 36 ± 10 µg/min). These findings indicate that within the remnant kidney, Ang II promotes sodium retention but does not have an acutely reversible effect on glomerular pressure or permselectivity.