Regulation of pancreatic acinar cell function
Regulation of pancreatic acinar cell function
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DOI：
10.1097/01.mog.0000239863.96833.c0
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发表时间：
2006-09-01
影响因子：
2.5
通讯作者：
Williams, John A.
中科院分区：
文献类型：
--
作者：
Williams, John A.
综述的目的最近的调查胰腺腺泡细胞功能的调节，导致了更详细的了解消化酶的合成和分泌的调节机制。这篇评论确定和上下文，进一步我们的理解，在这一领域。最近的研究结果腺泡细胞上的促分泌素受体，特别是毒蕈碱和胆囊收缩素，已被更好地确定和表征。细胞内钙离子的复杂控制，如三磷酸肌醇，细胞离子泵和膜通道的细胞内信使已变得更加清楚地了解，包括细胞器的鉴定螯合细胞内钙离子。在Ca ~（2+）驱动的胞吐作用领域，对酶原颗粒上的蛋白质，特别是Rabs和SNARE蛋白的研究取得了进展，并对肌动蛋白丝的动态变化进行了研究。最后，已经取得了相当大的进展，在了解机制调节胰腺生长的营养物质和以下pancreatectomy或pancreatitis.Summary了解机制，调节胰腺腺泡细胞功能有助于我们了解正常胰腺功能和疾病，如胰腺炎和胰腺癌的改变。
Purpose of review Recent investigations into the regulation of pancreatic acinar cell function have led to a more detailed understanding of the mechanisms regulating digestive enzyme synthesis and secretion. This review identifies and puts into context those articles which further our understanding in this area.Recent findings The secretagogue receptors present on acinar cells, especially muscarinic and cholecystokinin, have been better identified and characterized. The complex control of intracellular Ca2+ by intracellular messengers such as inositol trisphosphate, cellular ion pumps and membrane channels has become more clearly understood, including the identification of organelles sequestering intracellular Ca2+. In the area Ca2+ driven exocytosis, progress has been made in understanding the proteins present on the zymogen granules, especially Rabs and SNARE proteins, and the dynamic changes in actin filaments, Secretagogues have also been shown to enhance the translation of new protein by activation of the mammalian target of rapamycin pathway. Finally, considerable progress has been made in understanding the mechanisms regulating pancreatic growth in response to nutrients and following pancreatectomy or pancreatitis.Summary Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to our knowledge of normal pancreatic function and alterations in diseases such as pancreatitis and pancreatic cancer.