The rodent granular convoluted tubule cell - An update
The rodent granular convoluted tubule cell - An update
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DOI：
10.1076/ejom.34.3.221.13033
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发表时间：
1996-08-01
期刊：
影响因子：
--
通讯作者：
Ueha, T
中科院分区：
文献类型：
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作者：
Gresik, EW;Hosoi, K;Ueha, T
啮齿类动物下颌下腺颗粒曲管细胞处于复杂的发育和多激素调节下。最近的研究结果表明，GCT细胞也合成转化生长因子α（TGF-α），肝细胞生长因子，红细胞分化因子内皮素，胰岛素样生长因子，以及一些新的雄激素依赖性蛋白的未知功能。垂体切除小鼠的GCT为研究基因表达的多激素调节提供了一个方便的模型。啮齿动物SMG的GCT系统也是研究激素受体的富有成效的模型。
The cells of the granular convoluted tubule (GCT) of the rodent submandibular gland (SMG) are under complex developmental and multihormonal regulation. Recent findings indicate that GCT cells also synthesize transforming growth factor alpha (TGF-alpha), hepatocyte growth factor, erythroid differentiation factor endothelin, and insulin-like growth factor, as well as several novel androgen-dependent proteins of unknown function. The GCTs of hypophysectomized mice provide a convenient model to study multihormonal regulation of gene expression. The GCT system of the rodent SMG also is a fruitful model for study of hormone receptors.