Regulatory frameworks for copper considering chronic exposures of the population
Regulatory frameworks for copper considering chronic exposures of the population
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DOI：
10.1093/ajcn/88.3.863s
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发表时间：
2008-09-01
影响因子：
7.1
通讯作者：
L'Abbe, Mary R.
中科院分区：
文献类型：
--
作者：
Cockell, Kevin A.;Bertinato, Jesse;L'Abbe, Mary R.
铜是一种必需的营养素，过量的铜是有毒的。均衡饮食的铜摄入量似乎满足了大多数健康人的需求，因为明显的缺乏和毒性很少见。然而，由于目前可用于评估铜状况的生物标志物的局限性，以及可用于确定可容忍的上限摄入量的数据不足，一些不确定性仍然存在。目前与食品强化、营养补充剂和饮用水有关的政策和法规似乎在许多人口中提供足够的铜摄入量方面是有效的，尽管在某些情况下可能会通过过度强化、补充或饮用水暴露而导致高水平的暴露。评估人类人群铜暴露的监测和监测计划应继续进行，并应随着新的生物标志物的出现而改进。
Copper is an essential nutrient that is toxic in excess. Copper intakes from a balanced diet appear to meet the needs of most healthy individuals, because overt deficiency and toxicity are rare. Some uncertainty, however, persists because of limitations in currently available biomarkers used to assess copper status and the paucity of data available to establish tolerable upper levels of intake. Current policies and regulations pertaining to food fortification, nutritional supplements, and drinking water appear to be effective in providing for adequate copper intakes in many populations, although high levels of exposure, through overzealous fortification, supplementation, or drinking water exposure, may be possible under some circumstances. Surveillance and monitoring programs to evaluate copper exposures of human populations should continue and should be refined as new biomarkers become available.