INVESTIGATION OF THE INFLUENCE OF THYROID LOCATION ON IODINE-131 S VALUES.
INVESTIGATION OF THE INFLUENCE OF THYROID LOCATION ON IODINE-131 S VALUES.
复制标题
甲状腺位置对 IODINE-131 S 值影响的调查。
DOI：
10.1093/rpd/ncaa027
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发表时间：
2020
影响因子：
1
通讯作者：
Lee,Choonsik
中科院分区：
文献类型：
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作者：
Yeom,YeonSoo;Villoing,Daphnée;Greenstein,Natasha;Kitahara,CariM;Folio,LesR;Kim,ChanHyeong;Lee,Choonsik
使用固定甲状腺模型的参考计算体模的~(131)I和S值，可能会导致甲状腺位置与参考体模不同的患者出现显著的剂量学误差。在这项研究中，我们通过检查40名成年男性和女性患者的计算机断层扫描图像集来研究个体甲状腺位置的差异。随后，对国际放射防护委员会(ICRP)的成年男性和女性网状参考模体的甲状腺位置进行了调整，以匹配在该数据集中观察到的甲状腺的最高位置、平均位置和最低位置。将甲状腺调节的体模实施到Geant4蒙特卡罗程序中，计算总共30个靶区的甲状腺位置相关的~(131)I-S值(RT-←)。男性和女性患者甲状腺位置的最大变异分别为39 mm和36 mm。男性和女性患者的平均甲状腺位置与ICRP参考体模显示出很好的一致性。在大多数靶区，甲状腺位置相关的碘-131和S的值与参考模体的差异可达3倍。在剂量重建中使用甲状腺位置相关的S值应有助于量化接受碘-131治疗的甲亢和甲状腺癌患者的流行病学调查中的剂量学不确定度。
The use of iodine-131 S values based on reference computational phantoms with fixed thyroid model may lead to significant dosimetric errors in patients who may have different thyroid location from the reference phantoms. In the present study, we investigated individual thyroid location variation by examining the computed tomography image sets of 40 adult male and female patients. Subsequently, the thyroid location of the adult male and female mesh-type reference phantoms of the International Commission on Radiological Protection (ICRP) was adjusted to match each the highest, mean and the lowest locations of the thyroid observed in this dataset. The thyroid-adjusted phantoms were implemented into the Geant4 Monte Carlo code to calculate thyroid location-dependent iodine-131 S values (rT← thyroid) for a total of 30 target regions. The maximum variation among the observed thyroid locations was 39 mm and 36 mm for male and female patients, respectively. The mean thyroid locations of both male and female patients showed a good agreement with the ICRP reference phantoms. The thyroid location-dependent Iodine-131 S values were significantly different from the reference phantoms for most target regions by up to a factor of 3. The use of thyroid location-dependent S values in dose reconstructions should help quantify the dosimetric uncertainty in epidemiologic investigations of patients receiving iodine-131 therapy for hyperthyroidism and thyroid cancer.