Effect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing age
Effect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing age
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DOI：
10.1016/j.jtemb.2018.04.029
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发表时间：
2018-01-01
影响因子：
3.5
通讯作者：
Pizarro, Fernando
中科院分区：
文献类型：
--
作者：
Candia, Valeria;Rios-Castillo, Israel;Pizarro, Fernando
简介：微量营养素缺乏症是世界范围内最重要的公共卫生问题之一，缺铁性贫血是最常见的微量营养素缺乏症。缺铁常与缺钙并存，铁和钙的补充常重叠。这导致了对这两种矿物质之间的相互作用的研究，以及钙是否会抑制肠道中的铁吸收。目的：确定不同钙盐对禁食育龄妇女非血红素铁生物利用度的影响。对27名育龄妇女（35-45岁）进行了一项随机单盲试验，分为2组（分别为n1 = 13和n2 = 14）。在四个不同的日子里，在禁食过夜后，他们接受了5 mg FeSO 4形式的Fe（用Fe-55或Fe-59标记）和800 mg氯化钙、葡萄糖酸钙、柠檬酸钙、碳酸钙、乳酸钙、硫酸钙或磷酸钙形式的元素钙。两组均使用氯化钙作为对照盐。用放射性同位素Fe-59或Fe-55标记铁，并通过红细胞掺入放射性Fe来测量铁的吸收。结果：800 mg元素钙（柠檬酸钙）使非血红素铁的生物利用度显著降低（重复测量ANOVA，F = 3.79，p = 0.018）。在测试的各种钙盐中，柠檬酸钙是唯一一种能减少非-空腹服用时血红素铁相对于氯化钙对照的生物利用度。这些结果表明，抑制非血红素铁吸收在禁食的个人是依赖于钙盐的问题，而不仅仅是依赖于钙的存在。
Introduction: Micronutrient deficiencies are one of the most important public health issues worldwide and iron (Fe) deficiency anemia is the most prevalent micronutrient deficiency. Iron deficiency often coexists with calcium deficiency and iron and calcium supplementation often overlap. This has led to investigations into the interaction between these two minerals, and whether calcium may inhibit iron absorption in the gut.Objective: To determine the effect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing age.Methods: A randomized and single blinded trial was conducted on 27 women of childbearing age (35-45 years old) divided into 2 groups (n1 = 13 and n2 = 14, respectively). On four different days, after an overnight fast, they received 5 mg of Fe as FeSO4 (labeled with Fe-55 or Fe-59) with 800 mg of elemental calcium in the form of either calcium chloride, calcium gluconate, calcium citrate, calcium carbonate, calcium lactate, calcium sulfate or calcium phosphate. Calcium chloride was used as the control salt in both groups. Iron was labeled with the radioisotopes Fe-59 or Fe-55, and the absorption of iron was measured by erythrocyte incorporation of radioactive FeResults: 800 mg of elemental calcium as calcium citrate produced a significant decrease in non-heme iron bioavailability (repeated measures ANOVA, F = 3.79, p = 0.018).Conclusion: Of the various calcium salts tested, calcium citrate was the only salt that decreased non-heme iron bioavailability relative to the calcium chloride control when taken on an empty stomach. These results suggest that inhibition of non-heme iron absorption in fasted individuals is dependent upon the calcium salt in question and not solely dependent on the presence of calcium.