Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy.
Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy.
复制标题
显性遗传性橄榄脑桥小脑萎缩的选择性延迟交替缺陷。
DOI：
10.1016/0278-2626(91)90001-o
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
Freedman,M
中科院分区：
文献类型：
--
作者：
el-Awar,M;Kish,S;Oscar-Berman,M;Robitaille,Y;Schut,L;Freedman,M
In order to characterize more completely the nature of the frontal lobe-type cognitive changes in patients with dominantly inherited olivopontocerebellar atrophy (OPCA) we administered two tasks sensitive to frontal system dysfunction, delayed alternation (DA) and delayed response (DR), to 12 patients from one OPCA family. Affected members from this family have previously been shown to have a marked and widespread cerebral (including frontal) cortical cholinergic reduction as severe as that observed in Alzheimer's disease. Performance on DA, but not on DR, was significantly impaired in the OPCA patients compared to that in the controls. We suggest that the DA deficits in OPCA could be a consequence of a loss of cholinergic innervation to orbitofrontal or possibly temporal cortical areas and/or damage to the integrity of the cerebellofrontal neuronal connections.
