Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?
Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?
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DOI：
10.1111/myc.12387
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发表时间：
2015-10-01
期刊：
影响因子：
4.9
通讯作者：
Denning, D. W.
中科院分区：
文献类型：
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作者：
Parkes-Ratanshi, R.;Achan, B.;Denning, D. W.
乌干达的艾滋病毒流行突出了隐球菌和念珠菌感染是重要的机会性真菌感染。然而，其他真菌疾病的负担没有得到很好的描述。我们的目的是估计乌干达真菌感染的负担。回顾了乌干达真菌病的所有流行病学文献。如果没有乌干达的数据，则使用全球或东非的数据。复发性阴道念珠菌病估计每年发生在375540名乌干达妇女;念珠菌感染孕妇每年影响多达651600名妇女。每年约有45000例艾滋病毒相关的口腔和食管念珠菌病病例。每年有多达3000例结核病后慢性肺曲霉病病例。估计有40392人患有哮喘相关的真菌疾病。据估计，乌干达每年有130万名学龄儿童患上脑膜炎。每年约有800名艾滋病毒阳性成人患耶氏肺孢子虫肺炎（PJP），每年多达42 000名儿童患PJP。每年估计有4000例隐球菌病例。据估计，乌干达每年有250万人感染真菌。隐球菌和PJP每年导致大约28000例成人和儿童死亡。我们建议复制隐球菌病的研究模型，以调查和发展乌干达其他真菌病的管理策略。
The HIV epidemic in Uganda has highlighted Cryptococcus and Candida infections as important opportunistic fungal infections. However, the burden of other fungal diseases is not well described. We aimed to estimate the burden of fungal infections in Uganda. All epidemiological papers of fungal diseases in Uganda were reviewed. Where there is no Ugandan data, global or East African data were used. Recurrent vaginal candidiasis is estimated to occur in 375 540 Uganda women per year; Candida in pregnant women affects up to 651600 women per year. There are around 45000 HIV-related oral and oesophageal candidosis cases per year. There are up to 3000 cases per year of post-TB chronic pulmonary aspergillosis. There are an estimated 40392 people with asthma-related fungal conditions. An estimated 1300000 cases of tinea capitis occur in school children yearly in Uganda. There are approximately 800 HIV-positive adults with Pneumocystis jirovecii pneumonia (PJP) annually and up to 42 000 children with PJP per year. There are an estimated 4000 cryptococcal cases annually. There are an estimated 2.5 million fungal infections per year in Uganda. Cryptococcus and PJP cause around 28000 deaths in adults and children per year. We propose replicating the model of research around cryptococcal disease to investigate and development management strategies for other fungal diseases in Uganda.