The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
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发表时间：
2002-06
影响因子：
5.7
通讯作者：
A. Gartel;A. Tyner
中科院分区：
文献类型：
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作者：
A. Gartel;A. Tyner
当细胞增殖和细胞死亡之间的平衡被破坏时，癌症就会发生，随后的异常增殖会导致肿瘤生长。细胞周期蛋白依赖性激酶抑制剂 p21 在应激后由 p53 依赖性和非依赖性机制诱导，并且 p21 的诱导可能导致细胞周期停滞。作为一种增殖抑制剂，p21 有望在预防肿瘤发展中发挥重要作用。这一观点得到了数据的支持，表明 p21 缺失的小鼠更容易发生自发性和诱导性肿瘤发生，并且 p21 与其他肿瘤抑制因子协同作用以防止小鼠肿瘤进展。然而，最近的一些研究指出，p21除了作为细胞增殖的抑制剂外，还在许多系统中充当细胞凋亡的抑制剂，这可能抵消其作为生长抑制剂的肿瘤抑制功能。在当前的综述中，我们讨论了 p21 在调节细胞死亡中的作用及其在癌症中表达的潜在相关性。
Cancer develops when the balance between cell proliferation and cell death is disrupted, and the ensuing aberrant proliferation leads to tumor growth. The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and -independent mechanisms following stress, and induction of p21 may cause cell cycle arrest. As a proliferation inhibitor, p21 is poised to play an important role in preventing tumor development. This notion is supported by data indicating that p21-null mice are more prone to spontaneous and induced tumorigenesis, and p21 synergizes with other tumor suppressors to protect against tumor progression in mice. However, a number of recent studies have pointed out that in addition to being an inhibitor of cell proliferation, p21 acts as an inhibitor of apoptosis in a number of systems, and this may counteract its tumor-suppressive functions as a growth inhibitor. In the current review, we discuss the role of p21 in regulating cell death and the potential relevance of its expression in cancer.