High-Performance Biosensing Using Arrays of Plasmonic Nanotubes
High-Performance Biosensing Using Arrays of Plasmonic Nanotubes
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DOI：
10.1021/nn9015828
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发表时间：
2010-04-01
期刊：
影响因子：
17.1
通讯作者：
Pollard, Robert J.
中科院分区：
文献类型：
--
作者：
McPhillips, John;Murphy, Antony;Pollard, Robert J.
我们表明，能够支持等离子体共振的对齐的金纳米管阵列可用作生物分子结合反应中的高性能折射率传感器。提出了一种检测纳米管结构内外壁传感能力的方法。等离子体激元纳米管的灵敏度被发现增加的纳米管壁暴露，和内外壁的传感特性被示出是不同的。有限元模拟显示出良好的定性与观察到的行为。独立的金纳米管显示体积灵敏度在250 nm的区域内每折射率单位和信噪比优于1000蛋白质结合后，这是非常有竞争力的国家的最先进的无标记传感器。
We show that aligned gold nanotube arrays capable of supporting plasmonic resonances can be used as high performance refractive index sensors in biomolecular binding reactions. A methodology to examine the sensing ability of the inside and outside walls of the nanotube structures is presented. The sensitivity of the plasmonic nanotubes is found to increase as the nanotube walls are exposed, and the sensing characteristic of the inside and outside walls is shown to be different. Finite element simulations showed good qualitative agreement with the observed behavior. Free standing gold nanotubes displayed bulk sensitivities in the region of 250 nm per refractive index unit and a signal-to-noise ratio better than 1000 upon protein binding which is highly competitive with state-of-the-art label-free sensors.