Patterns of cortical thickness and surface area in early Parkinson's disease
Patterns of cortical thickness and surface area in early Parkinson's disease
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DOI：
10.1016/j.neuroimage.2010.12.043
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发表时间：
2011-03-15
期刊：
影响因子：
5.7
通讯作者：
Monchi, Oury
中科院分区：
文献类型：
--
作者：
Jubault, Thomas;Gagnon, Jean-Francois;Monchi, Oury
特发性帕金森病（PD）是一种基于运动症状诊断的神经退行性疾病，但也包括认知和视觉空间缺陷。虽然已知PD最初影响皮层下区域，但尸检研究表明，在疾病过程中，皮层也表现出神经元丢失。到目前为止，pd相关的皮质损伤模式仍然不清楚，因为疾病引起的异质性，也部分是因为方法学问题，如基于体素的形态测量法的局限性。本研究使用皮质测量法，一种将局部表面与厚度解耦的技术，以获得更好的PD皮质形态学模式图像。我们获得了33名健康对照（HC）和49名PD患者的MRI体积，提取了局部皮质厚度和表面积，并为每个参与者建立了组和年龄函数模型。两组的平均皮质厚度在整个皮质上没有差异，而PD组的平均表面积明显更大。PD组双侧顶叶、右侧额上回、左侧扣带皮层和左侧岛叶皮层局部表面积增大。PD组右侧楔前叶皮层变薄与年龄相关，HC组没有。此外，与对照组相比，PD组左侧内侧辅助运动区（SMA）和右侧背侧SMA前区皮质变薄。最后，我们发现左颞极厚度与疾病持续时间以及双侧枕皮质和布洛卡区相关。这些结果表明PD的病因学与特定的皮质改变有关，这可以解释随着疾病的发展而出现的认知缺陷。最后，我们在枕叶皮层观察到的结果作为疾病持续时间的功能可能表明pd相关视觉空间缺陷的增加，这有时会导致疾病后期的幻觉。在未来，mri生成的皮质测量与其他行为标记相结合，可能被证明是一种有用的诊断工具，可以表征PD患者运动和认知缺陷的演变。(C) 2010爱思唯尔公司版权所有。
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder diagnosed on the basis of motor symptoms, but that also includes cognitive and visuo-spatial deficits. Though PD is known to initially affect subcortical regions, the cortex also exhibits neuronal loss in the course of the disease as post mortem studies have shown. So far, PD-related pattern of cortical damage remains unclear, because of disease-caused heterogeneity, and also in part because of methodological issues such as the limitations of Voxel Based Morphometry. Here corticometry was used, a technique that decouples local surface from thickness, to obtain a better picture of PD corticomorphometric patterns.We acquired MRI volumes for 33 healthy controls (HC) and 49 PD patients, extracted local cortical thickness and surface area and modeled both of them as a function of group and age for each participant. Cortical thickness averaged on the whole cortex did not differ between the two groups while mean surface area was significantly larger in the PD group. The bilateral parietal lobule, the right superior frontal gyrus, the left cingulate cortex and the left insular cortex exhibited larger local surface area in the PD group. The right precuneus exhibited cortical thinning associated with age in the PD group and not in the HC group. Furthermore, cortical thinning was observed in the PD group compared with the control group in the left medial supplementary motor area (SMA) and in the right dorsal pre-SMA. Finally, we found the left temporal pole thickness to correlate with disease duration, as well as the bilateral occipital cortex and Broca's area. These results suggest that PD etiology is associated with specific cortical alterations, which could account for cognitive deficits that arise as the disease evolves. Finally, our results observed in the occipital cortex as a function of disease duration may indicate the increase in PD-related visuo-spatial deficits, which can sometimes result in hallucinations later on in the disease. In the future, MRI-generated corticometry, combined with additional behavioral markers, may prove to be a useful diagnosis tool to characterize the evolution of motor and cognitive deficits in PD. (C) 2010 Elsevier Inc. All rights reserved.