Development and performance evaluation of Time-over-Threshold based digital PET (TODPET2) scanner using SiPM/Ce:GAGG-arrays for non-invasive measurement of blood RI concentrations
Development and performance evaluation of Time-over-Threshold based digital PET (TODPET2) scanner using SiPM/Ce:GAGG-arrays for non-invasive measurement of blood RI concentrations
复制标题
使用 SiPM/Ce:GAGG 阵列对基于阈值时间的数字 PET (TODPET2) 扫描仪进行开发和性能评估，用于无创测量血液 RI 浓度
DOI：
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发表时间：
2017
期刊：
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通讯作者：
Y. Usuki
中科院分区：
文献类型：
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作者：
M. Yoshino;K. Kamada;Y. Shoji;Akira Yoshikawa;K. Shimazoe;A. Lipovec;Hiroyuki Takahashi;K. Fujiwara;Miwako Takahashi;Toshimitsu Momose;S. Ito;K. Tsutsumi;T. Endo;Hiroki Sato;Y. Usuki
我们使用硅光电倍增管 (SiPM) 阵列和像素化 Ce:Gd3(Ga, Al)5O12 (Ce:GAGG) 闪烁体开发了基于阈值时间的数字 PET (TODPET2) 断层扫描仪，专用于无创测量血液 RI 浓度。该探测器由排列在 12 × 12 通道上的 1.57 × 1.57 mm2 SiPM 芯片和 1.6 × 1.6 × 15 mm3 Ce:GAGG 闪烁体组成，两者都作为单独的读出系统工作。探测器开发完成后，我们制作了由 8 个 SiPM/Ce:GAGG 探测器阵列组成的 PET 龙门架，将信号发送到电流比较型超阈值时间 (TOT) ASIC 进行像素的单独读出。我们开发的 PET 扫描仪具有 25 毫米轴向视野 (FOV) 和 60 毫米横向视野。采用最大似然估计法 (MLEM) 重建的 FOV 中心空间分辨率为 0.98 mm (FWHM)。使用22Na点源测量系统的灵敏度为1.31%。最后，还使用注射了多种浓度的 18FDG 的 5 mm 直径注射器测量了对 RI 浓度变化的时间响应。
We developed Time-over-Threshold based digital PET (TODPET2) tomograph using silicon photomultipliers (SiPM) arrays coupled with pixelized Ce:Gd3(Ga, Al)5O12 (Ce:GAGG) scintillators dedicated for non-invasive measurement of blood RI concentrations. The detector consists of 1.57 × 1.57 mm2 SiPM chips and 1.6 × 1.6 × 15 mm3 Ce:GAGG scintillators arranged on a 12 × 12 channel, both working as individual readout systems. After the development of the detector, we fabricated the PET gantry composed of 8 pieces of SiPM/Ce:GAGG detector array which signals were sent to the current-comparing type time-over-threshold (TOT) ASIC for individual readout of pixels. The PET scanner which we developed has 25 mm axial field-of-view (FOV) and 60 mm transaxial FOV. The spatial resolution reconstructed with maximum likelihood estimation method (MLEM) is 0.98 mm (FWHM) at the center of FOV. The sensitivity of the system is measured to be 1.31% using 22Na point source. Finally, timing response to changes in RI concentration was also measured using 5 mm diameter syringe injected with several concentrations of 18FDG.