Controlling of bone morphogenetic protein signaling.
Controlling of bone morphogenetic protein signaling.
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DOI：
10.1016/j.cellsig.2009.12.007
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发表时间：
2010-06
影响因子：
4.8
通讯作者：
S. Zeng;Jia Chen;Hong Shen
中科院分区：
文献类型：
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作者：
S. Zeng;Jia Chen;Hong Shen
骨形态发生蛋白（BMPs）是一种多功能的生长因子，在胚胎发育、骨骼发育和细胞命运决定中起着关键作用。它们的信号通过细胞内信号介质从细胞膜传递到细胞核。目前，不同的信号通路已被确定，并详细阐述了参与信号调控的调节子网络。本文就骨形成蛋白信号通路的研究进展作一综述，分别从细胞外水平、细胞内水平、细胞核内Smad相互作用因子和非Smad依赖性信号通路等方面阐述了骨形成蛋白信号通路的调控机制。
Bone morphogenetic proteins (BMPs) are multifunctional growth factors and play crucial roles during embryonic development, skeletal development, and cell fate determination. Their signals are transduced from cell membrane to the nucleus through intracellular signaling mediators. At present, different signaling pathways have been identified, and elaborate of network of regulators involved in the signaling control. The aim of the present review is to describe the recent understanding of BMPs signaling with emphasis on the regulation of its signal transduction at extracellular level, intracellular level, Smad-interacting factors in the nucleus, and Smad-independent signaling pathways, respectively.