HSP100/Clp proteins: a common mechanism explains diverse functions.
HSP100/Clp proteins: a common mechanism explains diverse functions.
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DOI：
10.1016/s0968-0004(96)10038-4
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发表时间：
1996-08
影响因子：
13.8
通讯作者：
E. C. Schirmer;J. Glover;M. Singer;S. Lindquist
中科院分区：
文献类型：
--
作者：
E. C. Schirmer;J. Glover;M. Singer;S. Lindquist
HSP100/Clp蛋白是一个新发现的蛋白家族，具有多种功能，如增强对高温的耐受性，促进特定细胞底物的蛋白质水解和转录调节。HSP100/Clp蛋白也以多种特定模式合成，并且在真核生物中定位于不同的亚细胞区室。最近的数据表明，分解高阶蛋白质结构和聚集体的共同能力统一了这个多样化家族的分子功能。
The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription. HSP100/Clp proteins are also synthesized in a variety of specific patterns and, in eukaryotes, are localized to different subcellular compartments. Recent data suggest that a common ability to disassemble higherorder protein structures and aggregates unifies the molecular functions of this diverse family.