EXPOSURE OF PATIENTS TO PHTHALATES FROM POLYVINYL-CHLORIDE TUBES AND BAGS DURING DIALYSIS
EXPOSURE OF PATIENTS TO PHTHALATES FROM POLYVINYL-CHLORIDE TUBES AND BAGS DURING DIALYSIS
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DOI：
10.1159/000184165
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发表时间：
1987-04-01
期刊：
影响因子：
2.5
通讯作者：
OSTELIUS, J
中科院分区：
文献类型：
--
作者：
NASSBERGER, L;ARBIN, A;OSTELIUS, J
对患者在透析过程中接触到聚氯乙烯(PVC)管子和塑料袋中的增塑剂邻苯二甲酸二乙基己酯(DEHP)的情况进行了调查。对DEHP从血液透析管向血浆迁移的体外研究表明，DEHP的迁移系数为7.7微克/毫升/小时。人工肾不影响DEHP的血浆浓度。单次血液透析计算的暴露量可能与使用持续非卧床腹膜透析(CAPD)的年总暴露量一样多。PVC袋中的CAPD流体含有低浓度的DEHP及其水解产物邻苯二甲酸单(2-乙基己基)酯(MEHP)。同时接受CAPD和血液透析的患者的血清中这些邻苯二甲酸酯被用气相色谱分析。一组尚未接受透析治疗的患者作为对照。在任何情况下都不能检测到MEHP。17例血液透析患者透析后血清DEHP浓度为0.8~4.2微克/毫升，4例CAPD患者为0.1~0.9微克/毫升。3例CAPD患者和所有透析前患者均未检出DEHP(0.1u.g/ml)。
The exposure of patients to the plasticizer di(2-ethylhexyl)phthalate (DEHP) from polyvinyl chloride (PVC) tubes and bags during dialysis has been investigated. In vitro studies of the migration of DEHP from hemodialysis tubes into plasma revealed a migration coefficient of 7.7 .mu.g/ml/h. An artificial kidney did not influence the plasma concentration of DEHP. The calculated exposure from a single hemodialysis can be as much as the total annual exposure using continuous ambulatory peritoneal dialysis (CAPD). CAPD fluids in PVC bags contain low concentrations of DEHP and its hydrolysis product mono-(2-ethylhexyl)phthalate (MEHP). These phthalates were analyzed in serum from patients receiving both CAPD and hemodialysis using gas chromatography. A group of patients not yet on dialysis treatment was used as control. In no case could MEHP be detected. The DEHP concentration was 0.8-4.2 .mu.g/ml serum in the 17 hemodialysis patients after dialysis and 0.1-0.9 .mu.g/ml in 4 of the CAPD patients. In 3 of the CAPD and all of the predialysis patients, DEHP could not be detected (< 0.1 .mu.g/ml).