Neuroprotective clinical strategies for Parkinson's disease.
Neuroprotective clinical strategies for Parkinson's disease.
复制标题
帕金森病的神经保护临床策略。
DOI：
10.1002/ana.410320725
复制
发表时间：
1992
影响因子：
11.2
通讯作者：
Shoulson,I
中科院分区：
文献类型：
--
作者：
Shoulson,I
Increasing knowledge of the role of brain iron in health and disease has prompted consideration of therapeutic strategies aimed at attenuating the effects of iron and its untoward oxidative consequences. The success of this approach is critically dependent on a better understanding of the pathogenesis of Parkinson's disease. The controlled trial “Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism” (DATATOP) represents a clinical strategy to detect neuroprotective effects of antioxidative interventions. Validation of reliable biological markers of nigral degeneration is central to development of therapies that exert genuine neuroprotective effects in slowing the progression and preventing the onset of Parkinson's disease.
