Acoustic Methods for Increasing the Cavitation Initiation Pressure Threshold.
Acoustic Methods for Increasing the Cavitation Initiation Pressure Threshold.
复制标题
增加空化开始压力阈值的声学方法。
DOI：
10.1109/tuffc.2018.2867793
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Hall TL
中科院分区：
文献类型：
--
作者：
Alavi Tamaddoni H;Duryea AP;Vlaisavljevich E;Xu Z;Hall TL
组织疗法是一种组织消融方法，它利用聚焦的高放大器超声来产生一种机械分数的空化气泡云。空化气泡云可能会在组织疗法期间缩小或“锐化”焦点区域，从而产生更精确的且定义的病变，这也可能是一种使软组织在质地上的较低的脉冲及其在静脉相比的效力，这可能是一种积极地保护软组织的方法。三分不同的培养基：使用的水，牛琼脂糖凝胶和牛肝脏内部信号。
Histotripsy is a tissue ablation method that utilizes focused high amplitude ultrasound to generate a cavitation bubble cloud that mechanically fractionates tissue. Effective histotripsy depends on initiation, control, and maintenance of cavitation bubble clouds in the targeted area. In this study, we hypothesized that a low pressure acoustic pulse sequence applied before and/or during histotripsy therapy would increase the cavitation initiation pressure threshold and growth of cavitation bubble clouds. This technique could shrink or “sharpen” the focal zone during histotripsy to produce more precise and well defined lesions with minimal collateral damage. It may also be a way to actively protect soft tissue from cavitation damage during lithotripsy by increasing the pressure threshold for bubble cloud initiation. We applied these low amplitude acoustic pulse sequences before and during histotripsy treatments with PRF of 1 and 100 Hz, in three different mediums: water, tissue phantom agarose gel, and bovine liver in-vitro. Acoustic backscatter signals and optical imaging were used to detect and monitor initiation, maintenance and growth of the resulting cavitation bubble cloud. Results demonstrated that the use of low amplitude acoustic pulse sequences could increase the cavitation pressure amplitude threshold by 20% in the targeted area.