The CSAT methamphetamine treatment program: Research design accommodations for "real world" application
The CSAT methamphetamine treatment program: Research design accommodations for "real world" application
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DOI：
10.1080/02791072.2000.10400223
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发表时间：
2000-04-01
影响因子：
2.8
通讯作者：
Ling, W
中科院分区：
文献类型：
--
作者：
Huber, A;Lord, RH;Ling, W
由药物滥用治疗中心资助的甲基苯丙胺治疗方案（MTP）的目标是实施矩阵门诊模式，并与现有的社区治疗方法进行比较。“西部三个州（加州、蒙大拿和夏威夷）的七个组织被选中参加这个随机、对照、多地点的项目，这是迄今为止最大的甲基苯丙胺（MA）依赖治疗试验。在每个研究中心招募的150名MA依赖患者被随机分配接受Matrix模型（一种强化门诊治疗的手动程序）或研究中心的标准治疗（“照常治疗”）。“参与者在入院时、治疗期间每周、计划出院时以及入院后6个月和12个月进行评估。依赖性测量评估药物使用、HIV风险行为、生活质量和患者满意度的变化。将进行成本分析，以量化治疗成本并确定成本与临床结局之间的关联。社区网站的优势和局限性的现实需要对原始研究设计进行一些调整。这一多地点项目的经验也将为其他努力提供一个模式，将基于研究的治疗方法转移到社区环境中。本文描述了该项目的主要目标，研究设计的背景和基本原理，研究计划的简要说明，以及为保护科学完整性而实施的方法。
The Methamphetamine Treatment Program (MTP), funded by the Center for Substance Abuse Treatment, has the objectives of implementing the Matrix outpatient model and evaluating that model in comparison to the existing community "treatments as usual." Seven organizations in three western states (California, Montana, and Hawaii) were selected to participate in this randomized, controlled, multisite project in what constitutes the largest trial to date of treatment for methamphetamine (MA) dependence. One hundred fifty MA-dependent patients recruited at each site are randomly assigned to receive either the Matrix model, a manualized program of intensive outpatient treatment, or the site's standard treatment, "treatment as usual." Participants are evaluated at admission, weekly during treatment, at the time of scheduled discharge, and at six and 12 months after admission. Dependent measures assess changes in drug use, HIV risk behaviors, quality of life, and patient satisfaction. Cost analyses to quantify treatment costs and determine the association between costs and clinical outcomes will be conducted. A number of adjustments in the original study design have been necessitated by the realities of community sites' strengths and limitations. Experiences from this multisite project will also provide a model for other efforts to transfer research-based treatments into community settings. This article describes the main aims of the project, the background and rationale for the study design, a brief description of the research plan, and methods implemented to protect the integrity of the science.