Breast cancer stem cells: implications for therapy of breast cancer.

Breast cancer stem cells: implications for therapy of breast cancer.
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DOI:
10.1186/bcr2111
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发表时间:
2008
期刊:
Breast cancer research : BCR
影响因子:
--
通讯作者:
Lopez JA
Lopez JA
中科院分区:
其他
文献类型:
--
作者:
Morrison BJ;Schmidt CW;Lakhani SR;Reynolds BA;Lopez JA

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The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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