Minimal conjunctival limbal autograft for total limbal stem cell deficiency.
Minimal conjunctival limbal autograft for total limbal stem cell deficiency.
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DOI：
10.1097/qai.0b013e31815cea8b
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发表时间：
2008-07
期刊：
影响因子：
2.8
通讯作者：
Tseng SC
中科院分区：
文献类型：
--
作者：
Kheirkhah A;Raju VK;Tseng SC
目的报告自体60°结膜角膜缘移植联合羊膜移植治疗角膜缘干细胞缺乏症的临床效果。1例患有慢性全LSCD和化学烧伤引起的睑球粘连的患者的一只眼睛接受了睑球粘连松解术，从角膜表面去除血管翳，AM移植作为永久性移植物覆盖结膜和角膜表面，在上级角膜缘区域植入一个60° CLAU，并插入ProKera作为临时AM贴片覆盖CLAU。手术后，第6天在邻近CLAU的AM上的角膜上皮化明显，到第11天进展到通过水平中线，并在第18天完成。在1年的随访中，角膜表面保持稳定和光滑，基质相当大程度上恢复了透明度，基质中血管化消退。最佳矫正视力从20/400提高到20/50。结膜炎症完全消退，穹窿较深。一个60° CLAU联合AM移植作为永久移植物和临时补片，可以恢复由化学烧伤引起的全LSCD眼的整个角膜表面。
To report the results of one 60° conjunctival limbal autograft (CLAU) combined with amniotic membrane (AM) transplantation for an eye with total limbal stem cell deficiency (LSCD). One eye of a patient with chronic total LSCD and symblepharon caused by chemical burn was subjected to symblepharon lysis, removal of pannus from corneal surface, AM transplantation to cover the conjunctival and corneal surfaces as a permanent graft, one 60° CLAU to the superior limbal area, and insertion of ProKera as a temporary AM patch to cover the CLAU. After surgery, corneal epithelialization over the AM was evident adjacent to the CLAU on day 6, progressed to pass the horizontal midline by day 11, and was completed by day 18. During a follow-up of 1 year, the corneal surface remained stable and smooth, and the stroma considerably regained clarity with regression of midstromal vascularization. The best-corrected visual acuity improved from 20/400 to 20/50. The conjunctival inflammation completely resolved, and the fornices were deep. One 60° CLAU combined with AM transplantation as both a permanent graft and a temporary patch can restore the entire corneal surface in an eye with total LSCD caused by chemical burn.