Total Synthesis and Absolute Configuration of Simpotentin, a Potentiator of Amphotericin B Activity
Total Synthesis and Absolute Configuration of Simpotentin, a Potentiator of Amphotericin B Activity
复制标题
DOI：
10.1021/acs.orglett.9b01945
复制
发表时间：
2019-07-19
期刊：
影响因子：
5.2
通讯作者：
Nagamitsu, Tohru
中科院分区：
文献类型：
--
作者：
Ohtawa, Masaki;Shimizu, Eri;Nagamitsu, Tohru
合成了新的白念珠菌素B活性增强剂辛波汀（1）。我们的研究结果使1的所有立体异构体的访问和1的未知的绝对构型的澄清。此外，立体异构体之一是比1更好的阿替霉素B增效剂，并且是用于开发新型阿替霉素B增效剂的优异先导化合物。
The total synthesis of simpotentin (1), a new potentiator of amphotericin B activity against Candida albicans, was achieved. Our research results enabled the access of all stereoisomers of 1 and the elucidation of the unknown absolute configuration of 1. Furthermore, one of the stereoisomers is a better amphotericin B potentiator than 1 and is an excellent lead compound for the development of a novel amphotericin B potentiator.