Paralytic shellfish poisons.
Paralytic shellfish poisons.
复制标题
麻痹性贝类毒素。
DOI：
10.1007/978-3-7091-8717-3_3
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Shimizu,Y
中科院分区：
文献类型：
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作者：
Shimizu,Y
麻痹性贝类中毒（PSP）是由食用某些贝类引起的急性和经常致命中毒的毒素。这种现象早在史前时代就已为人所知。在霍尔斯特德关于有毒海洋生物的专著中，可以找到对这些事件的详尽记录。蛤蚌毒素(1)是最早在有毒贝类中发现的毒素，但近年来在各种标本中发现了一系列新的毒素。由于毒素对可兴奋膜中的钠通道具有独特的作用，因此它们作为药理学工具具有特殊的重要性。Schantz(2)和Shimizu(3)回顾了毒素研究的早期记录。
Paralytic shellfish poisons (PSP) are the toxins responsible for acute and often fatal poisonings caused by the consumption of certain shellfish. The phenomenon has been known since prehistoric times. A thorough docuinen tation of the incidents can be found in HALSTEAD’S treatise on poisonousmarine organisms (7). Saxitoxin (1) was the first toxin reeognized in toxic shellfish, but reeently a series of new toxins has been discovered in various specimens. The toxins have particular importance as pharmacological tools because of their unique action against sodium Channels in the excitable membrane. Earlier accounts of toxin research were reviewed by Schantz (2) and Shimizu (3).