Cross talk between the cytoplasm and nucleus during development and disease.
Cross talk between the cytoplasm and nucleus during development and disease.
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发育与疾病过程中细胞质与细胞核之间的相互交流 。
DOI：
10.1016/j.gde.2016.03.007
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发表时间：
2016-04
影响因子：
4
通讯作者：
L. Wallrath;J. Bohnekamp;T. Magin
中科院分区：
文献类型：
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作者：
L. Wallrath;J. Bohnekamp;T. Magin
机械转导是细胞外的机械刺激被质膜成分感知并作为信号通过终止于细胞核的细胞质传递的过程。细胞核通过改变基因表达来对这些信号做出反应。在机械转导过程中，复杂的蛋白质网络负责细胞质和细胞核之间的串扰。这些蛋白质包括细胞膜受体、细胞质细丝、连接细胞核和细胞质的LINC复合体成员，以及连接染色质的核膜蛋白。机械转导在发育过程中也起着关键作用。此外，机械转导的中断可能会导致基因表达的变化，这是疾病致病机制的基础。
Mechanotransduction is a process whereby mechanical stimuli outside the cell are sensed by components of the plasma membrane and transmitted as signals through the cytoplasm that terminate in the nucleus. The nucleus responds to these signals by altering gene expression. During mechanotransduction, complex networks of proteins are responsible for cross talk between the cytoplasm and the nucleus. These proteins include cell membrane receptors, cytoplasmic filaments, LINC complex members that bridge the nucleus and cytoplasm, and nuclear envelope proteins that connect to the chromatin. Mechanotransduction also plays a critical role in development. Furthermore, it is possible that disrupted mechanotransduction leads to changes in gene expression that underlie the pathogenic mechanisms of disease.