Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow
Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow
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时间分辨近红外技术用于床边绝对脑血流监测
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
K. St. Lawrence
中科院分区：
文献类型：
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作者：
M. Diop;K. Tichauer;J. Elliott;Mark Migueis;Ting;K. St. Lawrence
神经重症监护的主要焦点是监测受伤的大脑，以检测可能损害脑血流（CBF）的有害事件。由于目前的非侵入性床边方法只能间接评估血流，本研究的目标是开发一种光学技术测量绝对CBF。建立了一种时间分辨近红外（NIR）装置，并在仿组织模型中证明了其准确测量光学特性变化的能力。结合时间分辨系统与团注追踪法，使用染料吲哚菁绿色（ICG）作为血管内血流示踪剂测量CBF。脑血流量测量新生仔猪和比较，CBF同时测量使用先前开发的连续波近红外方法。在三种条件下用这两种技术获得测量值：正常碳酸血症、高碳酸血症和颈动脉闭塞。使用TR-NIR系统采集的平均CBF值（N = 3）在闭塞期间为31.9 ± 11.7 ml/100 g/min，在正常碳酸血症时为39.7 ± 1.6 ml/100 g/min，在高碳酸血症时为58.8 ± 9.9 ml/100 g/min。结果表明，开发的TR-NIR技术具有测量CBF变化的灵敏度;然而，CBF测量值比CW-NIRS技术获得的值低约25%。
A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF). Since current non-invasive bedside methods can only indirectly assess blood flow, the goal of this research was to develop an optical technique for measuring absolute CBF. A time-resolved near-infrared (NIR) apparatus was built and its ability to accurately measure changes in optical properties was demonstrated in tissue-mimicking phantoms. The time-resolved system was combined with a bolus-tracking method for measuring CBF using the dye indocyanine green (ICG) as an intravascular flow tracer. Cerebral blood flow was measured in newborn piglets and for comparison, CBF was concurrently measured using a previously developed continuous-wave NIR method. Measurements were acquired with both techniques under three conditions: normocapnia, hypercapnia and following occlusion of the carotid arteries. Mean CBF values (N = 3) acquired with the TR-NIR system were 31.9 ± 11.7 ml/100g/min during occlusion, 39.7 ± 1.6 ml/100g/min at normocapnia, and 58.8 ± 9.9 ml/100g/min at hypercapnia. Results demonstrate that the developed TR-NIR technique has the sensitivity to measure changes in CBF; however, the CBF measurements were approximately 25% lower than the values obtained with the CW-NIRS technique.