Phosphoramidite Ligands in iridium-catalyzed allylic substitution
Phosphoramidite Ligands in iridium-catalyzed allylic substitution
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DOI：
10.1002/chem.200501180
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发表时间：
2006-04-14
影响因子：
4.3
通讯作者：
Ditrich, K
中科院分区：
文献类型：
--
作者：
Polet, D;Alexakis, A;Ditrich, K
在铱催化的烯丙基取代反应中采用了一种新的磷酰胺配体。这允许在多种底物和亲核试剂上具有高的区域和对映体选择性。由于采用支链底物所得到的反应具有立体专一性，因此尝试了动力学分解反应。从动力学角度详细探讨了这种配体令人印象深刻的效率的起源，以及取代基在胺部分的邻位中的作用。
A new phosphoramidite ligand was used in the iridium-catalyzed allylic substitution reaction. This permitted high regio- and enantioselectivities on a wide variety of substrates and nucleophiles. Because of the stereospecificity of the reaction obtained by using branched substrates, a kinetic resolution reaction was attempted. The origin of the impressive efficiency of this ligand in terms of kinetics was explored in detail, as was the role of the substituent in the ortho-position of the amine moiety.