Modifications in surgical implantation of the Penn State electric total artificial heart.
Modifications in surgical implantation of the Penn State electric total artificial heart.
复制标题
宾夕法尼亚州立大学电动全人工心脏手术植入的修改。
DOI：
10.1016/s0003-4975(00)02640-0
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Pierce,WS
中科院分区：
文献类型：
--
作者：
Hoenicke,EM;StrangeJr,RG;Weiss,WJ;Snyder,AJ;Rawhouser,MA;Rosenberg,G;Prophet,GA;PaeJr,WE;Sun,BC;Pierce,WS
BackgroundTwo modifications of the surgical implantation protocol for the Penn State Total Artificial Heart (ETAH) were evaluated: Phrenic nerve ischemia was prevented by minimizing dissection and traction; and hemostasis was augmented and ETAH cuff anastomoses reinforced by using fibrin glue.MethodsThirteen Holstein calves underwent orthotopic surgical implantation of the Penn State ETAH between February 1998 and August 2000. Mean hemodynamic and laboratory chemistry variables from the first postoperative week were compared between calves receiving the original (n = 7) and modified (n = 6) protocol.ResultsCalves assigned to the modified protocol displayed an improvement in the Po2/Fio2ratio compared to original (419.4 ± 17.5 vs 336.3 ± 35.4, respectively; p = 0.05). All additional parameters were equivalent between groups. The percent survival of animals receiving the modified protocol at 2, 4, and 12 weeks was higher than that of animals that underwent the original protocol. Original-protocol calf deaths consisting of hemothorax (n = 3), and respiratory failure (n = 1) were prevented in the modified protocol.ConclusionsOur results suggest that manipulations in surgical protocol may promote increased survival in calves implanted with the Penn State ETAH.
