High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study
High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study
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高膳食酸负荷与胰岛素抵抗相关：Furukawa营养与健康研究
DOI：
10.1016/j.clnu.2015.03.008
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发表时间：
2016-04-01
影响因子：
6.3
通讯作者：
Mizoue, Tetsuya
中科院分区：
文献类型：
--
作者：
Akter, Shamima;Eguchi, Masafumi;Mizoue, Tetsuya
背景与目的：酸碱失衡被认为在包括2型糖尿病在内的某些心脏代谢异常中起重要作用，然而，缺乏将饮食中的酸负荷与糖代谢联系起来的流行病学证据。我们研究了日本工人的饮食酸负荷与胰岛素抵抗(IR)、胰岛素分泌和血糖状况的关系。方法：研究对象为1732名19-69岁的日本工人，他们在定期体检时完成了健康调查。饮食摄入量使用经过验证的简要饮食历史问卷进行评估。潜在肾酸负荷(PRAL)和净内源性酸产(NEAP)评分由营养素摄入量得出。用多水平线性回归模型估计空腹胰岛素、空腹血糖、稳态模型胰岛素抵抗评分(HOMA-IR)、P细胞功能稳态模型评分(HOMA-β)和糖化血红蛋白(HbAlc)的平均值，并调整潜在的混杂变量。结果：PRAL与HOMA-IR评分呈正相关(P趋势=0.045)；多变量调整后的HOMA-IR得分(95%可信区间)分别为0.88(0.82~0.94)、0.92(0.86~0.98)、0.92(0.86~0.98)和0.94(0.88~1.01)。在NEAP和HOMA-IR评分之间也观察到类似的关联(P-趋势=0.03)。在分层分析中，这些积极关联仅限于体重指数较低的受试者(
Background & aims: Acid-base imbalance has been suggested to play an important role in certain cardio-metabolic abnormalities, including type 2 diabetes; however, epidemiological evidence linking dietary acid load to glucose metabolism is lacking. We examined the association of dietary acid load with markers of insulin resistance (IR), insulin secretion, and blood glucose status among Japanese workers.Methods: The study subjects were 1732 workers, aged 19-69 years, who completed a health survey at a periodic checkup. Dietary intake was assessed using a validated brief diet history questionnaire. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores were derived from nutrient intake. A multilevel linear regression model was used to estimate the means of fasting insulin, fasting plasma glucose, homeostatic model assessment of IR (HOMA-IR) score, homeostatic model assessment of P-cell function (HOMA-beta) score and glycated hemoglobin (HbAlc) level with adjustment for potential confounding variables.Results: PRAL was positively associated with HOMA-IR score (P-trend = 0.045); the multivariable-adjusted means (95% confidence intervals) for the HOMA-IR scores for the lowest through the highest quartiles of PRAL were 0.88 (0.82-0.94), 0.92 (0.86-0.98), 0.92 (0.86-0.98), and 0.94 (0.88-1.01). A similar association was observed between NEAP and HOMA-IR scores (P-trend = 0.03). In the stratified analyses, these positive associations were confined to subjects with lower BMIs (