Hepatitis B Vaccination among 1999-2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage
Hepatitis B Vaccination among 1999-2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage
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DOI：
10.3390/ijerph15122915
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发表时间：
2018-12-01
影响因子：
--
通讯作者：
Liang, Hui
中科院分区：
文献类型：
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作者：
Hu, Yu;Chen, Yaping;Liang, Hui
本研究旨在调查1999年至2017年中国东部浙江省出生队列的B型肝炎疫苗（Hep B）覆盖率及其完整性和及时性。从浙江省免疫信息系统中提取1999年1月1日至2017年6月31日出生儿童的人口学特征和乙肝B疫苗接种记录。首剂乙肝B（乙肝1型）的及时性定义为目标人群中出生后24小时内接受乙肝1型的儿童比例。乙型肝炎（Hep B）的完整性定义为7岁之前完成三剂乙型肝炎（Hep B）系列的儿童比例。描述了目标人群的人口统计学特征。描述了每个出生队列中每剂Hep B的覆盖率、Hep B1的及时性和Hep B的完整性。应用Logistic回归模型分析影响乙肝疫苗接种及时性和乙肝B疫苗接种完整性的因素。乙肝疫苗接种率由90.3%提高到98.3%，乙肝疫苗接种率由88.8%提高到96.1%，乙肝疫苗接种率由86.4%提高到94.2%。Hep B1的及时性从80.3%提高到91.3%。Hep B的完整性从81.3%提高到91.5%。影响乙肝疫苗接种及时性的因素有分娩地点、移民身份、母亲文化程度、居住地经济发展水平等。影响B型肝炎疫苗接种完整性的因素有分娩地、移民身份、母亲文化程度、居住地经济发展水平、母亲职业、接种频率等。浙江省在乙肝的及时管理和乙肝B的完整性方面取得了显著的进步。为了加快进一步减少B型肝炎病毒传播的进展，需要进一步努力提高乙型肝炎疫苗接种的及时性，并减少本研究中确定的具有危险因素的弱势儿童的辍学率。
This study aimed to investigate the coverage of hepatitis B vaccine (Hep B) and its completeness and timeliness for birth cohorts from 1999 to 2017 in Zhejiang province, East China. Demographic characteristics and vaccination records of Hep B of children born from 1 January 1999 to 31 June 2017 were extracted from the Zhejiang provincial immunization information system. The timeliness of the first dose of Hep B (Hep B1) was defined as the proportion of children who received the Hep B1 within 24 h after birth among the target population. The completeness of Hep B was defined as the proportion of children who completed the three-dose series of Hep B before 7 years of age. The demographic characteristics of the target population were described. The coverage of each dose of Hep B, the timeliness of Hep B1, and the completeness of Hep B for each birth cohort were described. A logistic regression model was applied to detect the determinants of the timeliness of Hep B1 and the completeness of Hep B vaccination. The coverage of Hep B1 increased from 90.3% to 98.3%, the coverage of Hep B2 increased from 88.8% to 96.1%, and the coverage of Hep B3 increased from 86.4% to 94.2%. The timeliness of Hep B1 increased from 80.3% to 91.3%. The completeness of Hep B increased from 81.3% to 91.5%. The determinants of timeliness of Hep B1 included children's delivery place, immigration status, maternal education level, and economic development level of resident area. The determinants of completeness of Hep B included children's delivery place, immigration status, maternal education level, economic development level of resident area, maternal occupation, and frequency of vaccination service. Zhejiang province had achieved significant improvements in the timely administration of Hep B1 and the completeness of Hep B. To accelerate progress toward additional reductions in the transmission of hepatitis B virus, further efforts need to be focused on improving the timeliness of Hep B1 vaccination and reducing the drop-outs among disadvantaged children with the risk factors identified in this study.