Does growth hormone prevent or accelerate aging?
Does growth hormone prevent or accelerate aging?
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DOI：
10.1016/s0531-5565(98)00032-1
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发表时间：
1998-11-01
影响因子：
3.9
通讯作者：
Bronson, RT
中科院分区：
文献类型：
--
作者：
Bartke, A;Brown-Borg, HM;Bronson, RT
有充分的证据表明，在人类和实验动物中，血浆生长激素（GH）水平随着年龄的增长而下降，并且有大量证据表明，与年龄相关的身体成分变化可能是由GH- icf - i系统功能降低引起的。然而，过量的生长激素水平与肢端肥大症患者的预期寿命缩短和生长激素转基因小鼠的加速衰老症状有关。缺乏生长激素、催乳素和促甲状腺激素的遗传性矮鼠比它们正常的兄弟姐妹活得长得多。矮鼠延缓衰老的可能机制包括降低核心体温和减少氧化过程。这表明，关于生长激素预防和加速衰老的明显潜力的争议可以通过解释物种体内体型和寿命之间的负相关关系来调和。(C) 1998爱思唯尔科学有限公司
It is very well documented that plasma growth hormone (GH) levels decline with age in the human and in experimental animals, and there is considerable evidence that age-related changes in body composition may be caused by reduced function of the GH-ICF-I system. However, excessive GH levels are associated with reduced life expectancy in acromegalic patients and with symptoms of accelerated aging in GH transgenic mice. Hereditary dwarf mice deficient in GH, prolactin, and TSH live much longer than their normal siblings. Possible mechanisms of delayed aging in dwarf mice include lower core body temperature and reduced oxidative processes. It is suggested that the controversies concerning the apparent potential of GH to both prevent and accelerate aging may be reconciled by interpreting the results in light of the negative relationship between body size and life span within a species. (C) 1998 Elsevier Science Inc.