Candidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism
Candidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism
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DOI：
10.1007/s10803-010-1091-y
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发表时间：
2011-06-01
影响因子：
3.9
通讯作者：
Bruneau, Nicole
中科院分区：
文献类型：
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作者：
Gomot, Marie;Blanc, Romuald;Bruneau, Nicole
虽然抗拒改变是自闭症的一个主要特征，但对这种障碍的大脑过程仍然知之甚少。本研究的目的是通过电生理模式（MMN，P3 a）检查自闭症谱系障碍（ASD; N = 27）儿童听觉变化检测的神经基础，并测试这些是否与变化的不耐受性（使用BSE-R量表）定量相关。ASD表现出显着较短的MMN潜伏期和较大的P3 a比对照组，表明更大的倾向于切换到异常事件的注意。这些电生理异常显着更显着的儿童表现出更大的困难，在容忍的变化。这种非典型的神经生理学机制的变化感知，从而确定可能与自闭症的标志性行为表现之一。
Although resistance to change is a main feature of autism, the brain processes underlying this aspect of the disorder remain poorly understood. The aims of this study were to examine neural basis of auditory change-detection in children with autism spectrum disorders (ASD; N = 27) through electrophysiological patterns (MMN, P3a) and to test whether these are quantitatively related to intolerance of change (using the BSE-R scale). ASD displayed significantly shorter MMN latency and larger P3a than controls, indicating a greater tendency to switch attention to deviant events. These electrophysiological abnormalities were significantly more marked in children who displayed greater difficulties in tolerating change. The atypical neurophysiological mechanism of change perception identified might thus be associated with one of the hallmark behavioural manifestations of autism.