Parathyroid hormone stimulation of noncanonical Wnt signaling in bone
Parathyroid hormone stimulation of noncanonical Wnt signaling in bone
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DOI：
10.1196/annals.1402.047
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Partridge, Nicola C.
中科院分区：
文献类型：
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作者：
Bergenstock, Marika K.;Partridge, Nicola C.
在骨骼中，甲状旁腺激素（PTH）根据其给药方法发挥分解代谢或合成代谢作用。这种矛盾的作用导致使用PTH作为骨质疏松症的有效治疗。Wnt信号蛋白家族在多种事件中起着关键作用，这些事件对于动物的正常发育和生存是必要的，但它们在骨骼中的确切作用方法仍然难以捉摸。我们发现了Wnt-4和PTH之间的新联系。我们认为，在骨骼中，Wnt-4信号对PTH的反应涉及多种信号通路的串扰。这项工作希望进一步阐明骨中的Wnt信号传导，并提供对PTH在骨中的合成代谢作用的更好理解。
In bone, parathyroid hormone (PTH) exerts either a catabolic or an anabolic effect depending on its method of administration. This paradoxical action has led to the use of PTH as an effective treatment for osteoporosis. The Wnt family of signaling proteins has a critical role in multiple events, which are necessary for proper animal development and survival, yet their exact method of action in bone remains elusive. We have uncovered a novel link between Wnt-4 and PTH. We think that, in bone, Wnt-4 signaling in response to PTH implicates cross-talk of multiple signaling pathways. This work hopes to further elucidate Wnt signaling in bone and provide greater understanding of PTH's anabolic effects in bone.