4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase
4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase
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4-(磺酰氨基)苯基 α-D-吡喃葡萄糖苷作为酵母 α-葡萄糖苷酶的竞争性抑制剂
DOI：
10.1039/c39930001410
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
R. Taylor
中科院分区：
文献类型：
--
作者：
J. Briggs;A. Haines;R. Taylor
一系列4-（磺酰氨基）苯基α-D-吡喃葡萄糖苷中的某些成员是酵母α-葡萄糖苷酶的非常好的竞争性抑制剂，值得注意的是，4-（4-硝基苯磺酰氨基）苯基和4-（2-萘磺酰氨基）苯基α-D-吡喃葡萄糖苷（Ki，分别为4.8和3.1 µmol dm-3）对该酶的抑制作用上级1-脱氧野尻霉素（Ki，14.6 µmol dm-3）。
Certain members of a series of 4-(sulfonylamino)phenyl α-D-glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 µmol dm–3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 µmol dm–3) against this enzyme.