Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat.
Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat.
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发表时间：
1987-11
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通讯作者：
C. Stier;L. Roberts;P. Wong
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作者：
C. Stier;L. Roberts;P. Wong
9 α， 11 β -前列腺素F2 （9 α, 11 β - pgf2）是由PGD2通过11-酮还原酶的作用形成的一种新型PG，已被证明存在于肝脏，肺和肾脏中。据报道，9 α， 11 β - pgf2具有抗血小板聚集、血管收缩和支气管收缩的特性。为了进一步确定9 α， 11 β - pgf2在肾脏功能方面的生物活性，研究人员在麻醉的雄性Sprague-Dawley大鼠中进行了肾脏清除率测量。静脉输注高纯化的9 α， 11 β - pgf2（2.5微克/分钟，n = 9）可提高尿流量(28 +/- 6微升/分钟，P小于。0.05)，尿钠/钾(0.96 +/- 0.31,P <。05)，红细胞压积(0.5 +/- 0.3，体积/ 100ml， P <。05)和尿钠排泄（2.3 +/- 1.0 microEq/min）。PGF2 α（2.5微克/分钟）获得了类似的反应，但幅度更大。肾小球滤过率（GFR）和平均动脉压（MAP）未受影响。相比之下，PGD2（2.5微克/分钟）导致MAP降低，同时GFR、尿流量和钠排泄减少。以7.5微克/分钟的剂量给药9 α， 11 β - pgf2后，尿流量和钠排泄突然显著增加。9 α, 11 β - pgf2（2.5微克/分钟）在静脉注射2毫克/千克/小时的甲氯芬酯处理的大鼠中产生尿流量和钠和氯排泄的持续增加，表明这些反应不依赖于内源性PG合成。（摘要删节250字）
9 alpha, 11 beta-Prostaglandin F2 (9 alpha, 11 beta-PGF2) is a novel PG formed from PGD2 by the action of 11-ketoreductase which has been shown to exist in the liver, lung and kidneys. 9 alpha, 11 beta-PGF2 has been reported to possess platelet antiaggregatory, vasoconstrictor and bronchoconstrictor properties. To define further the biological activity of 9 alpha, 11 beta-PGF2, with respect to kidney function, studies were conducted in anesthetized male Sprague-Dawley rats prepared for renal clearance measurements. Intravenous infusion of highly-purified 9 alpha, 11 beta-PGF2 (2.5 micrograms/min, n = 9) elevated urine flow (28 +/- 6 microliter/min, P less than .05), urinary sodium/potassium (0.96 +/- 0.31, P less than .05), hematocrit (0.5 +/- 0.3, volumes/100 ml, P less than .05) and urinary sodium excretion (2.3 +/- 1.0 microEq/min). Similar responses but of greater magnitude were obtained with PGF2 alpha (2.5 micrograms/min). Glomerular filtration rate (GFR) and mean arterial pressure (MAP) were unaffected. In contrast, PGD2 (2.5 micrograms/min) resulted in decreases in MAP and concomitant reductions in GFR, urine flow and sodium excretion. Abrupt and pronounced increases in urine flow and sodium excretion were observed on administration of 9 alpha, 11 beta-PGF2 at 7.5 micrograms/min. 9 alpha, 11 beta-PGF2 (2.5 micrograms/min) produced consistent increases in urine flow and the excretion of sodium and chloride in rats treated with meclofenamate, 2 mg/kg/hr i.v., indicating that these responses were not dependent on endogenous PG synthesis.(ABSTRACT TRUNCATED AT 250 WORDS)