Blood-Brain Barrier as a Regulatory Interface
Blood-Brain Barrier as a Regulatory Interface
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DOI：
10.1159/000264398
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Banks, William A.
中科院分区：
文献类型：
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作者：
Banks, William A.
血脑屏障(BBB)是连接中枢神经系统和周围组织的通讯网络的重要组成部分，在控制与摄食相关的行为方面发挥着重要作用。具体地说，血脑屏障作为一个界面，限制和调节中枢神经系统和血液之间的物质交换。许多与进食有关的多肽和调节蛋白由外周组织产生，并与大脑中的受体一起被发现跨越了Bibb。血脑屏障对这些物质的渗透性的后果可以从不同的角度来看待。在这里，我们简要地考虑一下关于围巾和饮食的五种观点。一种生理学整合的观点强调血脑屏障是控制中枢神经系统和周围组织之间体液依赖性信号传递的管道。一种调节的观点强调，许多与进食有关的荷尔蒙的转运体本身都受到生理事件的调节。这意味着通过血脑屏障的血到脑的信号是状态依赖的，并能适应生物体的需要。病理功能障碍的观点显示了血脑屏障转运体的失调如何导致疾病。肥胖患者对瘦素的抵抗是由于其跨血脑屏障转运减少所致。一种进化观强调血脑屏障在进食中的作用是如何进化的，以及对一组饮食条件的适应如何在其他条件下导致适应不良。最后，探讨了这些观点对针对肥胖或厌食症的药物开发的影响。总体而言，这些观点表明，血脑屏障是饮食生理中不可或缺的一部分。版权所有(C)2010 S.Karger AG，巴塞尔
The blood-brain barrier (BBB) is an important component of the communication network that connects the central nervous system and peripheral tissues in the control of feeding-related behaviors. Specifically, the BBB acts as an interface that restricts and regulates the exchange of substances between the CNS and blood. Many of the eating-related peptides and regulatory proteins produced by peripheral tissues and with receptors in the brain have been found to cross the BIBB. The consequences of BBB permeability to these substances can be viewed from various perspectives. Here, we briefly consider five views relating the BIBB and eating. A view of physiologic integration emphasizes the BBB as a conduit that controls a humoral-dependent signaling between the CNS and peripheral tissues. A view of regulation emphasizes that the transporters for many of the eating-related hormones are themselves regulated by physiologic events. This means that blood-to-brain signaling across the BBB is state-dependent and adaptable to the needs of the organism. A view of pathologic dysfunction shows how dysregulation of BBB transporters can result in disease. Resistance to leptin caused by its decreased transport across the BBB in obesity is an example. An evolutionary view emphasizes how the role of the BBB in eating may have evolved and how adaptations to one set of eating conditions can result in maladaptations under other conditions. Finally, the implications of these views for drug development targeted at obesity or anorexia is explored. Overall, these views show the BBB is an integral part of the physiology of eating. Copyright (C) 2010 S. Karger AG, Basel