Determinants of Blood Pressure in Preschool Children The Role of Parental Smoking
Determinants of Blood Pressure in Preschool Children The Role of Parental Smoking
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DOI：
10.1161/circulationaha.110.958769
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发表时间：
2011-01-25
期刊：
影响因子：
37.8
通讯作者：
Wuehl, Elke
中科院分区：
文献类型：
--
作者：
Simonetti, Giacomo D.;Schwertz, Rainer;Wuehl, Elke
背景-高血压是心血管疾病的主要危险因素。虽然越来越多的证据表明，从童年到成年生活的血压跟踪，有关于遗传，产前，生物，行为，环境和社会决定因素的相对贡献，以childhood血压.Methods和Results-Blood血压和一系列潜在的人体测量，产前，环境，和高血压的家族危险因素，包括父母吸烟习惯，作为筛查项目的一部分，在4236名学龄前儿童（年龄5.7 +/- 0.4岁）中进行了测定。据报告，28.5%的父亲和20.7%的母亲吸烟，11.9%的父母都吸烟。除了典型的危险因素如体重指数、早产、低出生体重和父母高血压外，吸烟父母的儿童收缩压（+1.0 [95%置信区间，+0.5至+1.5] mm Hg; P = 0.0001）和舒张压（+0.5 [+0.03至+0.9] mm Hg; P = 0.03）均较高。父母吸烟独立影响收缩压（P = 0.001）即使校正了其他风险因素，如体重指数、父母高血压或出生体重，也会使前15%人群的收缩压升高21%。结论：在健康的学龄前儿童中，父母吸烟是高血压的独立危险因素，增加了其他家庭和环境危险因素。在家中和公共场所实施无烟环境可能会为幼儿提供长期的心血管益处。（循环。2011; 123：292-298）。
Background-Hypertension is the leading risk factor for cardiovascular disease. Although accumulating evidence suggests tracking of blood pressure from childhood into adult life, there is little information regarding the relative contributions of genetic, prenatal, biological, behavioral, environmental, and social determinants to childhood blood pressure.Methods and Results-Blood pressure and an array of potential anthropometric, prenatal, environmental, and familial risk factors for high blood pressure, including parental smoking habits, were determined as part of a screening project in 4236 preschool children (age 5.7 +/- 0.4 years). Smoking was reported by 28.5% of fathers and 20.7% of mothers, and by both parents 11.9%. In addition to classic risk factors such as body mass index, prematurity, low birth weight, and parental hypertension, both systolic (+1.0 [95% confidence interval, +0.5 to +1.5] mm Hg; P = 0.0001) and diastolic blood pressure (+0.5 [+0.03 to +0.9] mm Hg; P = 0.03) were higher in children of smoking parents. Parental smoking independently affected systolic blood pressure (P = 0.001) even after correction for other risk factors, such as body mass index, parental hypertension, or birth weight, increasing the likelihood of having a systolic blood pressure in the top 15% of the population by 21% (2% to 44%; P = 0.02).Conclusions-In healthy preschool children, parental smoking is an independent risk factor for higher blood pressure, adding to other familial and environmental risk factors. Implementing smoke-free environments at home and in public places may provide a long-term cardiovascular benefit even to young children. (Circulation. 2011; 123: 292-298.)