Application of Composite Hydrogels to Control Physical Properties in Tissue Engineering and Regenerative Medicine
Application of Composite Hydrogels to Control Physical Properties in Tissue Engineering and Regenerative Medicine
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DOI：
10.3390/gels4020051
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发表时间：
2018-05
期刊：
影响因子：
4.6
通讯作者：
Cassidy Sheffield;Kaylee M. Meyers;Emil Johnson;R. Rajachar
中科院分区：
文献类型：
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作者：
Cassidy Sheffield;Kaylee M. Meyers;Emil Johnson;R. Rajachar
用于在病理条件下以及急性和慢性损伤中恢复正常组织结构-功能关系的生物材料的开发是一个深入研究的领域。最近，将定制的或复合的水凝胶用于组织工程和再生医学已经试图更清楚地弥合天然组织和应用的生物材料之间的差距。通过在工程复合材料中应用传统概念，这些水凝胶代表了分层结构材料，这些材料更紧密地转化了改善组织结构和功能行为恢复所需的关键指导原则，包括物理，质量传输和生物学特性。对于一般的组织工程支架，更具体地说，在复合水凝胶材料中，这些特性中的每一种都提供了独特的品质，这些品质对于疾病和损伤后的适当增强和修复至关重要。本综述的主要重点是复合水凝胶材料的物理性能，特别是静态和动态力学性能，以及它们与天然组织结构的联系，最终是复合水凝胶的组织特异性应用。
The development of biomaterials for the restoration of the normal tissue structure–function relationship in pathological conditions as well as acute and chronic injury is an area of intense investigation. More recently, the use of tailored or composite hydrogels for tissue engineering and regenerative medicine has sought to bridge the gap between natural tissues and applied biomaterials more clearly. By applying traditional concepts in engineering composites, these hydrogels represent hierarchical structured materials that translate more closely the key guiding principles required for improved recovery of tissue architecture and functional behavior, including physical, mass transport, and biological properties. For tissue-engineering scaffolds in general, and more specifically in composite hydrogel materials, each of these properties provide unique qualities that are essential for proper augmentation and repair following disease and injury. The broad focus of this review is on physical properties in particular, static and dynamic mechanical properties provided by composite hydrogel materials and their link to native tissue architecture and, ultimately, tissue-specific applications for composite hydrogels.