Functional magnetic resource imaging assessment of altered brain function in hypothyroidism during working memory processing
Functional magnetic resource imaging assessment of altered brain function in hypothyroidism during working memory processing
复制标题
功能磁共振成像评估工作记忆处理过程中甲状腺功能减退症脑功能改变
DOI：
10.1530/eje-11-0046
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发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Zhang, Da-Ren
中科院分区：
文献类型：
--
作者：
He, Xiao-Song;Ma, Ning;Zhang, Da-Ren
内容：甲状腺功能减退症与包括工作记忆功能障碍在内的多种认知缺陷有关，其潜在的神经相关性很少研究。在这项研究中，甲状腺功能减退症的神经回路参与工作记忆加工的影响，探讨了功能磁共振成像（fMRI）。设计：使用功能磁共振成像，我们进行了一项纵向研究，调查在工作记忆任务，四个数字的向后回忆（BR）和向前回忆（FR），在甲状腺功能减退症患者和对照组的脑功能的变化。方法：对13例女性患者在服用左旋甲状腺素（L-T-4）治疗前和治疗后6个月进行了fMRI扫描，并对12例甲状腺功能正常的对照者进行了扫描。结果：甲减患者的记忆力明显低于正常对照组。此外，在双侧内侧前额叶皮质、后扣带皮质和左下半小叶，任务诱发失活（TID，任务依赖性神经活动相对于休息时的减少）在患者和对照组之间存在显著差异（P < 0.05）。这些区域被认为是任务负性网络的一部分，即默认模式网络（DMN）。具体地说，相对于对照组，患者表现出减少TID BR在FR。L-T-4治疗后，无论是不良的记忆状态，也没有TID的改变是detectedinpatient.Conclusion：甲状腺功能减退症是与工作记忆加工过程中的DMN区域内的TID的改变。这些探索性的发现可能意味着甲状腺功能减退症相关的认知功能障碍及其恢复的潜在神经相关性。
Context: Hypothyroidism is related to multiple cognitive deficits including working memory dysfunction, of which the underlying neural correlates were rarely studied. In this study, the impact of hypothyroidism on neural circuits involved in working memory processing was explored by functional magnetic resource imaging (fMRI).Design: Using fMRI, we conducted a longitudinal study investigating alterations of brain function during a working memory task, the four-digit backward recall (BR) and forward recall (FR), in hypothyroid patients and controls.Methods: fMRI scan was used in 13 female patients at two time points: before and after having been treated with levothyroxine (L-T-4) for similar to 6 months, and 12 matched euthyroid controls were also scanned. Wechsler Memory Scale-Chinese Revision was used to assess the memory states of each participant.Results: The hypothyroid patients showed poorer memory states than that in controls. Furthermore, significant differences of task-induced deactivation (TID, task-dependent decreases in neural activity relative to rest) between patients and controls were found in the bilateral medial prefrontal cortices, posterior cingulate cortices, and left inferior partial lobule (P < 0.05). These regions were considered as parts of a task-negative network, namely the default mode network (DMN). Concretely, relative to controls, patients showed diminished TID during BR in contrast to FR. After the L-T-4 treatment, neither the poor memory states nor the alteration of TID was detectable in patients.Conclusion: Hypothyroidism is related to alterations of TID within DMN regions during working memory processing. These exploratory findings may imply potential neural correlates in hypothyroidism-related cognitive deficits and their recoveries.