Graphene quantum dots as anti-inflammatory therapy for colitis
Graphene quantum dots as anti-inflammatory therapy for colitis
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DOI：
10.1126/sciadv.aaz2630
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发表时间：
2020-04-01
期刊：
影响因子：
13.6
通讯作者：
Kang, Kyung-Sun
中科院分区：
文献类型：
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作者：
Lee, Byung-Chul;Lee, Jin Young;Kang, Kyung-Sun
虽然石墨烯及其衍生物已被认为是几种仿生模型中潜在的纳米医学，但它们在免疫疾病中的特定作用仍然难以捉摸。石墨烯量子点（GQD）可能适用于治疗肠道疾病（IBD），因为它们在体内的毒性低，易于清除。在此，GQD被腹膜内注射到葡聚糖硫酸钠（DSS）诱导的慢性和急性结肠炎模型中，并且其功效已被证实。特别地，GQD通过抑制T（H）1/T（H）17极化有效地防止组织变性并改善肠道炎症。此外，GQD将巨噬细胞的极化从经典活化的M1转换为M2，并增强调节性T细胞（T-CTL）的肠浸润。因此，GQD通过调节免疫细胞有效地减弱过度炎症，表明它们可以用作治疗自身免疫性疾病（包括IBD）的有前景的替代治疗剂。
While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo and ease of clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)-induced chronic and acute colitis model, and its efficacy has been confirmed. In particular, GQDs effectively prevent tissue degeneration and ameliorate intestinal inflammation by inhibiting T(H)1/T(H)17 polarization. Moreover, GQDs switch the polarization of macrophages from classically activated M1 to M2 and enhance intestinal infiltration of regulatory T cells (T-regs). Therefore, GQDs effectively attenuate excessive inflammation by regulating immune cells, indicating that they can be used as promising alternative therapeutic agents for the treatment of autoimmune disorders, including IBDs.